Gut Dysbiosis Associated With Hepatitis C Virus Infection.
Background Little is known about the effect of hepatitis C virus (HCV) infection on gut microbiota and the relationship between alteration of gut microbiota and chronic hepatitis C (CHC) progression. We performed a comparative study of gut microbiota composition between CHC patients and healthy indi...
| Publicado en: | Clinical Infectious Diseases Vol. 67; no. 6; pp. 869 - 878 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
9/15/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131509934&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131509934 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10584838 46X jtl: Clinical Infectious Diseases issn: 10584838 maglogo: N pubinfo: dt: 9/15/2018 vid: 67 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 131509934 131509934 131509934 10.1093/cid/ciy205 131509934 ppf: 869 ppct: 9 formats: tig: atl: Gut Dysbiosis Associated With Hepatitis C Virus Infection. aug: au: Inoue, Takako Nakayama, Jiro Moriya, Kei Kawaratani, Hideto Momoda, Rie Ito, Kiyoaki Iio, Etsuko Nojiri, Shunsuke Fujiwara, Kei Yoneda, Masashi affil: Department of Clinical Laboratory Medicine, Nagoya City University Hospital sug: subj: Gut Microbiota Pathology Hepatitis C, Chronic Microbiology Disease Progression Human Comparative Studies Feces Analysis Sequence Analysis Methods RNA Analysis Hepatitis C, Chronic Diagnosis Alanine Aminotransferase Blood Liver Cirrhosis Familial and Genetic Carcinoma, Hepatocellular Streptococcus Lactobacillus Genome Urease Bacteroides Enterobacteriaceae Viridans Streptococci Metabolic Diseases Liver Cirrhosis Etiology Hepatitis C, Chronic Complications ab: Background Little is known about the effect of hepatitis C virus (HCV) infection on gut microbiota and the relationship between alteration of gut microbiota and chronic hepatitis C (CHC) progression. We performed a comparative study of gut microbiota composition between CHC patients and healthy individuals. Methods Fecal samples from 166 CHC patients were compared with those from 23 healthy individuals; the gut microbiota community was analyzed using 16S ribosomal RNA gene sequencing. CHC patients were diagnosed with persistently normal serum alanine aminotransferase without evidence of liver cirrhosis (LC) (PNALT, n = 18), chronic hepatitis (CH, n = 84), LC (n = 40), and hepatocellular carcinoma in LC (n = 24). Results Compared with healthy individuals, bacterial diversity was lower in persons with HCV infection, with a decrease in the order Clostridiales and an increase in Streptococcus and Lactobacillus. Microbiota dysbiosis already appeared in the PNALT stage with the transient increase in Bacteroides and Enterobacteriaceae. Predicted metagenomics of microbial communities showed an increase in the urease gene mainly encoded by viridans streptococci during CHC progression, consistent with a significantly higher fecal pH in CH and LC patients than in healthy individuals or those in the PNALT stage. Conclusions HCV infection is associated with gut dysbiosis, even in patients with mild liver disease. Additionally, overgrowth of viridans streptococci can account for hyperammonemia in CH and LC. Further studies would help to propose a novel treatment strategy because the gut microbiome can be therapeutically altered, potentially reducing the complications of chronic liver disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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