Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy.
Objectives: To evaluate correlations between tumour response to definitive chemoradiotherapy (CRT) in oesophageal squamous cell carcinoma (SCC) and histogram-derived apparent diffusion coefficient (ADC) parameters on diffusion-weighted MR images.Methods: Forty patients with clinical T3-4 oesophageal...
| Publicado en: | European Radiology Vol. 28; no. 10; pp. 4296 - 4306 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131578492&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131578492 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2018 vid: 28 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131578492 131578492 NLM29725833 10.1007/s00330-018-5439-6 NLM29725833 131578492 ppf: 4296 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy. aug: au: Kozumi, Maiko Ota, Hideki Yamamoto, Takaya Umezawa, Rei Matsushita, Haruo Ishikawa, Yojiro Takahashi, Noriyoshi Matsuura, Tomonori Takase, Kei Jingu, Keiichi affil: Department of Radiology, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, Japan sug: subj: Magnetic Resonance Imaging Methods Magnetic Resonance Imaging Predictive Value of Tests Male Aged Aged, 80 and Over Female Middle Age Scales Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Male Female ab: Objectives: To evaluate correlations between tumour response to definitive chemoradiotherapy (CRT) in oesophageal squamous cell carcinoma (SCC) and histogram-derived apparent diffusion coefficient (ADC) parameters on diffusion-weighted MR images.Methods: Forty patients with clinical T3-4 oesophageal SCC underwent concurrent CRT. MR examination at 3 T was performed 1-3 days prior to CRT. Readout-segmented echo-planar diffusion imaging was used to acquire ADC maps. Pre- and post-treatment CT examinations were performed. Histogram parameters (mean, 10th, 25th, 50th, 75th, 90th percentiles, skewness and kurtosis) of the ADC values were compared with post-treatment disease status based on RECIST and the tumour regression ratio.Results: None of the ADC parameters showed significant correlation with post-treatment status (range of Spearman's ρ values - 0.19 to 0.14, range of p values 0.22-0.47) or tumour regression ratio (range of Spearman's ρ values - 0.045 to 0.18, range of p values 0.26-0.96). Neither progression-free survival (PFS) (p = 0.17) nor overall survival (OS) (p = 0.15) was significantly different between the two groups corresponding to the lower (< median) and upper arms (≥ median) of the mean ADC values.Conclusions: Histogram-derived pretreatment ADC parameters were not predictive imaging biomarkers for tumour response to CRT in patients with oesophageal SCC.Key Points: • Apparent diffusion coefficient (ADC) values are derived from diffusion-weighted MR imaging. • High-resolution diffusion-weighted images are generated by readout-segmented echo-planar diffusion imaging. • Readout-segmented echo-planar diffusion-weighted imaging enabled evaluation of ADC parameters. • Pretreatment ADC parameters do not predict chemoradiotherapy response in patients with oesophageal carcinoma. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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