Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association?
Rationale: Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) has r...
| Publicado en: | Medicine Vol. 97; no. 34; pp. 1 - 6 |
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| Autores principales: | , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131629399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131629399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: Aug2018 vid: 97 iid: 34 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 131629399 131629399 NLM30142811 131629399 10.1097/MD.0000000000011933 NLM30142811 131629399 ppf: 1 ppct: 5 formats: tig: atl: Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association? aug: au: Lebrun, Delphine Robbins, Ailsa Hentzien, Maxime Toquet, Ségolène Plee, Julie Durlach, Anne Bouaziz, Jean-David Bani-Sadr, Firouzé Servettaz, Amélie affil: Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital, Reims, France. sug: subj: Lupus Erythematosus, Systemic Complications Pyoderma Gangrenosum Immunology Leg Female Face Adult Arthritis Impact Measurement Scales Scales Adult: 19-44 years Female ab: Rationale: Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) has rarely been reported.Patient Concerns: We report here 2 cases of this association.Diagnoses: The first case involves a 32-year-old woman who developed, 1 year after SLE diagnosis, 3 painful nodular lesions of PG on her face, and cervical area. The second case was observed in a 37-year-old woman referred for ulcerative nodular papules of PG on her legs, whereas she had been diagnosed with SLE 10 years before. SLE was inactive in the first case, whereas PG occurred during a lupus flare up in the second one.Interventions: We found 23 previous cases of SLE and PG in the literature with most cases (12/20) occurring during a lupus flare.Outcomes: Although rare, this association may be supported by common innate immunity dysregulation and abnormal neutrophil activation.Lessons: PG and other neutrophilic diseases reported in patients with SLE may be added to the large clinical spectrum of cutaneous lesions observed in SLE. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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