Teratogenic potential of nanoencapsulated vitamin A evaluated on an alternative model organism, the tunicate Ciona intestinalis.
Nano-encapsulation is a technology used to pack substances in order to enhance their stability and bioavailability, but this packing may interact with living systems, causing unexpected toxicity. Vitamin A (vit A) is a substance that has received attention, because in developed countries, the increa...
| Publicado en: | International Journal of Food Sciences & Nutrition Vol. 69; no. 7; pp. 805 - 814 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131640016&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131640016 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09637486 IJF jtl: International Journal of Food Sciences & Nutrition issn: 09637486 maglogo: Y pubinfo: dt: Nov2018 vid: 69 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 131640016 131640016 NLM29336191 10.1080/09637486.2017.1418843 NLM29336191 131640016 ppf: 805 ppct: 9 formats: tig: atl: Teratogenic potential of nanoencapsulated vitamin A evaluated on an alternative model organism, the tunicate Ciona intestinalis. aug: au: Pennati, Roberta Manenti, Raoul Stillitano, Antonella Ficetola, Gentile Francesco Scarì, Giorgio Mercurio, Silvia Menegola, Elena affil: Department of Environmental Science and Policy, University of Milan, Milan, Italy sug: subj: Invertebrates Drug Effects Vitamin A Teratogens Nanostructures Membranes, Artificial Vitamin A Administration and Dosage Animals Biological Availability Toxicity Tests Arthritis Impact Measurement Scales ab: Nano-encapsulation is a technology used to pack substances in order to enhance their stability and bioavailability, but this packing may interact with living systems, causing unexpected toxicity. Vitamin A (vit A) is a substance that has received attention, because in developed countries, the increasing availability of supplements is leading to its excessive intake. This study aims to compare teratogenic effects caused by exposure to the traditional formulation of vit A versus nano-encapsulated vit A. We used ascidian embryos as an alternative model. Ascidians are marine organisms closely related to vertebrates that share with them a body plan and developmental programme, including the morphogenetic role of retinoic acid (RA). Our data showed that the adverse effects of exposure to the same concentration of the two formulations were different, suggesting that the nano-encapsulation increased the bioavailability of the molecule, which could be better absorbed and metabolised to RA, the effective teratogenic substance. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|