Intravoxel incoherent motion (IVIM) at 3.0 T: evaluation of early renal function changes in type 2 diabetic patients.
Purpose: The purpose of this study was to evaluate the utility of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) parameters in identifying early renal function changes in diabetics.Methods: A total of 40 patients with type 2 diabetes mellitus and 20 healthy control subjects under...
| Publicado en: | Abdominal Radiology Vol. 43; no. 10; pp. 2764 - 2774 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131640983&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131640983 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Oct2018 vid: 43 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131640983 10.1007/s00261-018-1555-7 131640983 ppf: 2764 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Intravoxel incoherent motion (IVIM) at 3.0 T: evaluation of early renal function changes in type 2 diabetic patients. aug: au: Feng, You-Zhen Chen, Xiao-Qiao Yu, Juan Liu, Xiao-Ling Cheng, Zhong-Yuan Ren, Wei-Wei Feng, Lie Cai, Xiang-Ran affil: Medical Imaging Center, First Affiliated Hospital, Jinan University, No. 613 West Huangpu Avenue, Tianhe District, 510630, Guangzhou, China sug: ab: Purpose: The purpose of this study was to evaluate the utility of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) parameters in identifying early renal function changes in diabetics.Methods: A total of 40 patients with type 2 diabetes mellitus and 20 healthy control subjects underwent multiple b value DWI. The diabetic patients were stratified into two groups based on albuminuria category: NAU (normal to mildly increased albuminuria; ACR < 30 mg/g) and MAU (moderately increased albuminuria; 30 ≤ ACR < 300 mg/g). The mean cortical and medullary IVIM parameters (D, D*, f, and ADC) were calculated and compared among the different groups, and the correlation of ACR and eGFR was also calculated.Results: The present study revealed the limited water molecule diffusion and hyperperfusion of renal cortex and medulla in diabetic patients before proteinuria detection. Mean cortical and medullary D values negatively correlated with the ACR values in diabetics with 30 ≤ ACR < 300 mg/g, whereas no correlation was found between ACR values and other IVIM parameters.Conclusion: IVIM DWI might be helpful in noninvasively identifying early-stage DN. The IVIM parametric values are more sensitive than the ACR in detecting early-stage kidney changes. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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