Ambulatory blood pressure monitoring and neurocognitive function in children with primary hypertension.
Background: Children with primary hypertension have been reported to have diminished scores in measures of cognition. However, little is known about the relative correlation between office and ambulatory blood pressure (BP) and neurocognitive test performance, and whether short-term BP variability i...
| Publicado en: | Pediatric Nephrology Vol. 33; no. 10; pp. 1765 - 1772 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131661157&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131661157 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Oct2018 vid: 33 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131661157 131661157 131661157 10.1007/s00467-018-3954-y 131661157 ppf: 1765 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Ambulatory blood pressure monitoring and neurocognitive function in children with primary hypertension. aug: au: Kupferman, Juan C. Batisky, Donald L. Samuels, Joshua Adams, Heather R. Hooper, Stephen R. Wang, Hongyue Lande, Marc B. affil: Department of Pediatrics, Maimonides Medical Center, 977 48th Street, 11219, Brooklyn, NY, USA sug: subj: Essential Hypertension Diagnosis Blood Pressure Monitoring, Ambulatory Cognition Evaluation Neuropsychological Tests Methods Human Child Adolescence Odds Ratio Multivariate Analysis Systolic Pressure Psychological Tests Child: 6-12 years Adolescent: 13-18 years ab: Background: Children with primary hypertension have been reported to have diminished scores in measures of cognition. However, little is known about the relative correlation between office and ambulatory blood pressure (BP) and neurocognitive test performance, and whether short-term BP variability is associated with decreased neurocognitive function. We sought to determine whether ambulatory BP monitoring (ABPM) was more strongly associated with neurocognitive test performance compared with office BP, and whether increased short-term BP variability was associated with lower neurocognitive scores.Methods: Seventy-five subjects ages 10-18 years, with untreated primary hypertension, and 75 matched normotensive controls completed neurocognitive testing. All subjects had office BP and ABPM prior to neurocognitive testing.Results: On multivariate analyses, there was no significant association between office BP and neurocognitive tests. However, several ABPM parameters were significantly associated with neurocognitive test scores in the lower quartile, in particular 24 h SBP load and wake systolic blood pressure (SBP) index [Rey Auditory Verbal learning Test (RAVLT) List A Trial 1, 24 h SBP load, odds ratio (OR) = 1.02, wake SBP index, OR = 1.06; List A Total, 24 h SBP load, OR = 1.02, wake SBP index, OR = 1.06; Short Delay Recall, wake SBP index, OR = 1.06; CogState Maze delayed recall, 24 h SBP load, OR = 1.03, wake SBP index, OR = 1.08; Grooved Pegboard, 24 h SBP load, OR = 1.02; all p < 0.05]. In contrast, short-term BP variability measures were not associated with neurocognitive test performance.Conclusions: ABPM is superior to office BP in distinguishing hypertensive youth with lower neurocognitive test performance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|