MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder.
Conduct disorder (CD), a common psychiatric disorder in children and adolescents, is characterized by encroaching upon other rights and violations of age-appropriate social expectations repeatedly and persistently. Individuals with CD often have high aggressiveness and low inhibitory capacity. The m...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 27; no. 9; pp. 1159 - 1170 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131688396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131688396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2018 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131688396 131688396 131688396 10.1007/s00787-018-1170-8 131688396 ppf: 1159 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder. aug: au: Sun, Xiaoqiang Ma, Ren Jiang, Yali Gao, Yidian Wu, Qiong Dong, Daifeng Wang, Xiang Ming, Qingsen Yao, Shuqiao affil: Medical Psychological Center, The Second Xiangya Hospital, Central South University, No 139, Middle Renmin Road, 410011, Changsha, Hunan, People's Republic of China sug: subj: Genotype Child Behavior Disorders Familial and Genetic Oxidoreductases Child Behavior Disorders Diagnosis Task Performance and Analysis Magnetic Resonance Imaging Methods Adolescence Human Limbic System Alleles Gene Expression Male Heterozygote Frontal Lobe Cognition Adolescent: 13-18 years Male ab: Conduct disorder (CD), a common psychiatric disorder in children and adolescents, is characterized by encroaching upon other rights and violations of age-appropriate social expectations repeatedly and persistently. Individuals with CD often have high aggressiveness and low inhibitory capacity. The monoamine oxidase A (MAOA) gene has long been associated with aggression. Effects of MAOA genotype on inhibitory control have been examined in general population. Several studies had revealed reduced activation in prefrontal areas, especially the anterior cingulate cortex (ACC), in low-expression MAOA (MAOA-L) allele carriers compared to high-expression MAOA (MAOA-H) allele carriers. However, little is known about its genetic risk influences on inhibitory processes in clinical samples. In this study, functional magnetic resonance imaging (fMRI) was administered to a sample of adolescent boys with CD during the performance of a GoStop task, 29 of whom carrying MAOA-L allele and 24 carrying MAOA-H allele. Relative to MAOA-H carriers, MAOA-L carriers in CD showed more pronounced deactivation in the precuneus, supplementary motor area (SMA) and dorsal anterior cingulate cortex (dACC). Deactivation within the default mode network (DMN) and inhibitory-related areas in MAOA-L carriers may be related to compensation for low sensitivity to inhibition and/or an atypical allocation of cognitive resources. The results suggested a possible neural mechanism through which MAOA affects inhibitory processes in a clinical sample. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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