Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf.
Objective: Disuse and/or a non-weight-bearing condition changes muscle composition, with decreased skeletal muscle tissue and increased fat within (intramuscular adipose tissue, IntraMAT) and between (intermuscular adipose tissue, InterMAT) given muscles. Excessive adipose tissue contributes to dysf...
| Publicado en: | Skeletal Radiology Vol. 47; no. 11; pp. 1541 - 1550 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131779894&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131779894 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Nov2018 vid: 47 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131779894 131779894 NLM29948037 10.1007/s00256-018-2985-6 NLM29948037 131779894 ppf: 1541 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf. aug: au: Yoshiko, Akito Yamauchi, Koun Kato, Takayuki Ishida, Koji Koike, Teruhiko Oshida, Yoshiharu Akima, Hiroshi affil: Graduate School of Medicine, Nagoya University, Nagoya, Japan sug: subj: Adipose Tissue Muscular Disorders, Atrophic Immobilization Adverse Effects Metatarsal Bones Injuries Fibula Injuries Fractures Therapy Female Male Leg Thigh Muscular Disorders, Atrophic Etiology Muscular Disorders, Atrophic Pathology Magnetic Resonance Imaging Orthopedic Fixation Devices Adipose Tissue Pathology Weight-Bearing Crutches Metatarsal Bones Aged Muscle, Skeletal Middle Age Muscle, Skeletal Pathology Aged, 80 and Over Aged: 65+ years Middle Aged: 45-64 years Aged, 80 & over Female Male ab: Objective: Disuse and/or a non-weight-bearing condition changes muscle composition, with decreased skeletal muscle tissue and increased fat within (intramuscular adipose tissue, IntraMAT) and between (intermuscular adipose tissue, InterMAT) given muscles. Excessive adipose tissue contributes to dysfunctional and metabolically impaired muscle. How these adipose tissues change during orthopedic treatment (e.g., cast immobilization, daily use of crutches) is not well documented. This study aimed to quantify changes in IntraMAT, InterMAT, and thigh and calf muscle tissue during orthopedic treatment.Materials and Methods: We studied 8 patients with fifth metatarsal bone or fibular fractures. The ankle joint involved underwent plaster casting for approximately 4 weeks, with crutches used during that time. Axial T1-weighted MRI at the mid-thigh and a 30% proximal site at the calf were obtained to measure IntraMAT and InterMAT cross-sectional areas (CSAs) and skeletal muscle tissue CSA before treatment and 4 weeks afterward.Results: Thigh and calf muscle tissue CSAs were significantly decreased from before to after treatment: thigh, 85.8 ± 7.6 to 77.1 ± 7.3 cm2; calf, 53.3 ± 5.5 to 48.9 ± 5.0 cm2 (p < 0.05). None of the IntraMAT or InterMAT changes was statistically significant. There was a relation between the percentage change of thigh IntraMAT CSA and muscle tissue CSA (rs = -0.86, p < 0.01).Conclusions: The 4 weeks of treatment primarily induced skeletal muscle atrophy with less of an effect on IntraMAT or InterMAT. There is a risk of increasing IntraMAT relatively by decreasing skeletal muscle tissue size during orthopedic treatment. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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