Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder.
Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy (1H-MRS) to examine th...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 48; no. 10; pp. 3460 - 3474 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131819795&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131819795 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Oct2018 vid: 48 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131819795 131819795 131819795 10.1007/s10803-018-3613-y 131819795 ppf: 3460 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder. aug: au: Hegarty, John P. Weber, Dylan J. Cirstea, Carmen M. Beversdorf, David Q. affil: Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO, USA sug: subj: Brain Mapping Cerebellum Autism Spectrum Disorder Pathology Human Magnetic Resonance Imaging Methods Magnetic Resonance Spectroscopy Methods Glutamic Acid Glutamine GABA Frontal Lobe Adult Adolescence Pilot Studies Listening Speech Perception Adult: 19-44 years Adolescent: 13-18 years ab: Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy (1H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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