Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia.
Background: Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans. High levels of ketamine abuse are associated with persisting psychosis (KPP) in a minority of users. However, relatively little is known about cognitive function among KPP patients and whether t...
| Publicado en: | Schizophrenia Research Vol. 199; pp. 313 - 319 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Sep2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131848329&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131848329 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: Sep2018 vid: 199 pid: 1004 pub: Elsevier B.V. artinfo: ui: 131848329 131848329 NLM29510925 131848329 10.1016/j.schres.2018.02.049 NLM29510925 131848329 ppf: 313 ppct: 6 formats: tig: atl: Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia. aug: au: Cheng, Wan-Ju Chen, Chun-Hsin Chen, Chih-Ken Huang, Ming-Chyi Pietrzak, Robert H. Krystal, John H. Xu, Ke affil: Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan sug: subj: Substance Use Disorders Psychosocial Factors Psychology Excitatory Amino Acid Antagonists Adverse Effects Cognition Ketamine Adverse Effects Psychotic Disorders Psychosocial Factors Female Human Adult Male Excitatory Amino Acid Antagonists Administration and Dosage Ketamine Administration and Dosage Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Funding Source Adult: 19-44 years Female Male ab: Background: Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans. High levels of ketamine abuse are associated with persisting psychosis (KPP) in a minority of users. However, relatively little is known about cognitive function among KPP patients and whether the cognitive impairments associated with KPP resemble those of schizophrenia (SZ).Methods: We recruited 149 treatment-seeking patients, including nonpsychotic ketamine users (KNP, n=51), KPP (n=23), and SZ (n=75) patients. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate psychopathology and the Cogstate Brief Battery to assess cognitive function including psychomotor processing speed, attention, working memory, verbal and visual learning and memory, spatial problem solving, and social-emotional cognition.Results: Ketamine-dependent patients had an extensive history of ketamine use (average duration=7.1±4.2years, average consumption=3.8±2.7g per day). Although KPP patients used relatively less average ketamine daily dose than KNP patients, KPP patients exhibited significantly greater total PANSS score and subscale scores, while these scores in KPP and SZ patients did not differ significantly. After adjusting for demographic characteristics and antipsychotic dose, KPP and SZ patients showed impairments in spatial problem solving and verbal memory compared to KNP patients, but KPP and SZ patients did not significantly differ from each other.Conclusion: These data suggest that the symptom profile and cognitive impairments associated with persisting psychosis due to chronic heavy ketamine abuse resemble those of schizophrenia, while KNP patients showed significantly less severe symptom profile and cognitive impairment than KPP and SZ. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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