Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers.

Rationale: Antidepressant action has been linked to increased synaptic plasticity in which epigenetic mechanisms such as histone posttranslational acetylation could be involved. Interestingly, the histone deacetylases HDAC5 and SIRT2 are oppositely regulated by stress and antidepressants in mice pre...

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Bibliographic Details

Published in:	Psychopharmacology Vol. 235; no. 10; pp. 2831 - 2847
Main Authors:	Muñoz-Cobo, I., Erburu, M.M., Zwergel, C., Cirilli, R., Mai, A., Valente, S., Puerta, E., Tordera, Rosa M.
Format:	Journal Article
Published:	Springer Nature Oct2018
Online Access:	View this record in EBSCOhost