Contribution of cocaine-related cues to concurrent monetary choice in humans.
Rationale: Theoretical accounts highlight the importance of drug-related cues for the development and persistence of drug-taking behavior. Few studies have evaluated the ability of spatially contiguous drug cues to bias decisions between two concurrently presented non-drug reinforcers.Objective: Eva...
| Publicado en: | Psychopharmacology Vol. 235; no. 10; pp. 2871 - 2882 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132021644&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132021644 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Oct2018 vid: 235 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132021644 10.1007/s00213-018-4978-5 132021644 ppf: 2871 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Contribution of cocaine-related cues to concurrent monetary choice in humans. aug: au: Strickland, Justin C. Marks, Katherine R. Beckmann, Joshua S. Lile, Joshua A. Rush, Craig R. Stoops, William W. affil: Department of Psychology, University of Kentucky College of Arts and Sciences, 171 Funkhouser Drive, 40506-0044, Lexington, KY, USA sug: ab: Rationale: Theoretical accounts highlight the importance of drug-related cues for the development and persistence of drug-taking behavior. Few studies have evaluated the ability of spatially contiguous drug cues to bias decisions between two concurrently presented non-drug reinforcers.Objective: Evaluate the contribution of spatially contiguous cocaine cues to choice between two concurrently presented monetary reinforcersMethods: Participants with cocaine use disorder completed a cued concurrent choice task. Two cues (one cocaine and one control image) were presented side-by-side followed by concurrent monetary offers below each image. Concurrent choice was measured for cocaine-side advantageous, equal, and disadvantageous concurrent monetary offers. The primary dependent measure was bias for selecting cocaine-cued monetary reinforcers. Three experiments tested selectivity of cocaine-cued bias in individuals with a cocaine use history (Experiment 1), replication when including additional control trials (Experiment 2), and a potential attentional mechanism evaluated using eye-tracking technology (Experiment 3).Results: Significant and robust cocaine-cued bias at equal monetary value was observed in three experiments (mean percent choice = 65-77%) and higher Drug Abuse Screening Test (DAST) scores were associated with greater cocaine-choice bias. These experiments demonstrated that cocaine-cued bias was (1) selective to individuals with a cocaine use history, (2) specific to trials involving a cocaine cue, and (3) partially associated with attentional bias.Conclusions: These experiments provide evidence that drug-related cues can influence choice and potentially promote maladaptive decision making during concurrent choice events. Future research evaluating prospective associations of drug-cued bias with drug-associated behaviors will help reveal the clinical relevance for substance use disorder. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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