Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers.
Aims Dysfunctional brain reward circuitry, particularly in the nucleus accumbens (NAcc), has been proposed as a risk factor for alcohol use disorder (AUD). This risk factor may be evident in binge drinkers (BD), who are at high risk for developing AUD. We examined whole-brain and NAcc reactivity to...
| Published in: | Alcohol & Alcoholism. Supplement Vol. 52; no. 6; pp. 647 - 655 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
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Oxford University Press / USA
Nov2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132131985&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132131985 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13586173 AWR7 jtl: Alcohol & Alcoholism. Supplement issn: 13586173 maglogo: N pubinfo: dt: Nov2017 vid: 52 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 132131985 132131985 132131985 10.1093/alcalc/agx062 132131985 ppf: 647 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers. aug: au: Crane, Natania A Gorka, Stephanie M Weafer, Jessica Langenecker, Scott A Wit, Harriet de Phan, K. Luan affil: Department of Psychiatry, University of Illinois at Chicago, 1747 W Roosevelt Rd Chicago, IL 60608, USA sug: subj: Binge Drinking Prevention and Control Reward Brain Physiology Neural Pathways Alcoholism Risk Factors Human Games Task Performance and Analysis Magnetic Resonance Imaging Methods Cerebral Cortex Physiology Diagnosis, Brain ab: Aims Dysfunctional brain reward circuitry, particularly in the nucleus accumbens (NAcc), has been proposed as a risk factor for alcohol use disorder (AUD). This risk factor may be evident in binge drinkers (BD), who are at high risk for developing AUD. We examined whole-brain and NAcc reactivity to reward in BD compared to non-binge drinkers (NBD), hypothesizing that groups would differ in their neural reactivity and connectivity. Methods Healthy BD (N = 27) and NBD (N = 23)—none meeting AUD criteria—completed a reward-guessing game, the 'Doors' task, during functional magnetic resonance imaging. We conducted an exploratory whole-brain search for group differences, but given our a priori hypotheses, we also extracted activation from the NAcc to examine reactivity during reward (Win > Loss) and functional connectivity (FC) to the prefrontal cortex. Results Compared to NBD, BD exhibited greater activation in both the right and left NAcc during reward relative to loss. Additionally, NBD drinkers exhibited positive FC between the NAcc and dorsal anterior cingulate (dACC) whereas the BD showed negative FC between these regions. Furthermore, less NAcc–dACC FC was related to more past month alcohol use. Conclusions Our results provide preliminary evidence that BD exhibit greater NAcc activation during reward receipt relative to loss. This is consistent with the broader AUD literature and suggests aberrant neural reactivity may precede disorder onset. In addition, BD exhibited less NAcc–dACC FC, perhaps reflecting deficient regulation of activation to rewards compared to losses. This profile of reward brain circuitry could represent neural correlates of vulnerability for AUD. Short summary Healthy binge drinkers, at risk for alcohol use disorder, exhibited greater nucleus accumbens activation during reward relative to loss. In addition, binge drinkers exhibited reduced connectivity between the nucleus accumbens and dorsal anterior cingulate, which was associated with more past month alcohol use. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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