Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases.
Objectives: To empirically determine thresholds for volumetric assessment of response and progress of liver metastases in line with the unidimensional RECIST thresholds.Methods: Patients with metastatic colorectal cancer initially enrolled in a multicentre clinical phase-III trial were included. In...
| Publicado en: | European Radiology Vol. 28; no. 11; pp. 4839 - 4849 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Springer Nature
Nov2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132188030&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132188030 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2018 vid: 28 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132188030 132188030 NLM29736851 132188030 10.1007/s00330-018-5424-0 NLM29736851 132188030 ppf: 4839 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases. aug: au: Winter, Katharina S. Hofmann, Felix O. Thierfelder, Kolja M. Holch, Julian W. Hesse, Nina Baumann, Alena B. Modest, Dominik P. Stintzing, Sebastian Heinemann, Volker Ricke, Jens Sommer, Wieland H. D'anastasi, Melvin affil: Department of Radiology, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany sug: subj: Tomography, X-Ray Computed Methods Liver Neoplasms Drug Therapy Liver Neoplasms Treatment Outcomes Antineoplastic Agents Therapeutic Use Image Processing, Computer Assisted Aged Radiographic Image Enhancement Adult Reproducibility of Results Male Female Middle Age Human Retrospective Design Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objectives: To empirically determine thresholds for volumetric assessment of response and progress of liver metastases in line with the unidimensional RECIST thresholds.Methods: Patients with metastatic colorectal cancer initially enrolled in a multicentre clinical phase-III trial were included. In all CT scans, the longest axial diameters and volumes of hepatic lesions were determined semi-automatically. The sum of diameters and volumes of 1, ≤2 and ≤5 metastases were compared to all previous examinations. Volumetric thresholds corresponding to RECIST 1.1 thresholds were predicted with loess-regression. In sensitivity analysis, the concordances of proposed thresholds, weight-maximizing thresholds and thresholds from loess-regression were compared. Classification concordance for measurements of ≤2 metastases was further analyzed.Results: For measurements of ≤2 metastases, 348 patients with 629 metastases were included, resulting in 4,773 value pairs. Regression analysis yielded volumetric thresholds of -65.3% for a diameter change of -30%, and +64.6% for a diameter change of +20%. When comparing measurements of unidimensional RECIST assessment with volumetric measurements, there was a concordance of significant progress (≥+20% and ≥+65%) in 88.3% and of significant response (≤-30% and ≤-65%) in 85.0%.Conclusions: In patients with hepatic metastases, volumetric thresholds of +65% and -65% were yielded corresponding to RECIST thresholds of +20% and -30%.Key Points: • Volumes and diameters of liver metastases from colorectal cancer were determined. • Volumetric thresholds of +65%/-65% corresponding to RECIST 1.1 are proposed. • Comparing both measurements, concordance was 88.3% (significant progress) and 85.0% (significant response). pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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