Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial.
Objective: The aim of this randomized double‐blind and placebo‐controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the mean level of Archaea. Methods: Fifty‐nine (59) subjects were randomly assigned to receive scaling and root planing (SRP) alone...
| Publicado en: | International Journal of Dental Hygiene Vol. 16; no. 4; pp. 569 - 576 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132394609&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132394609 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16015029 K8M jtl: International Journal of Dental Hygiene issn: 16015029 maglogo: Y pubinfo: dt: Nov2018 vid: 16 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 132394609 132394609 132394609 10.1111/idh.12347 132394609 ppf: 569 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial. aug: au: Ramiro, FS Lira, EAG Soares, GMS Retamal‐Valdes, B Feres, M Figueiredo, LC Faveri, M affil: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos Brazil sug: subj: Periodontitis Therapy Antibiotics Therapeutic Use Gingiva Microbiology Bacteria Drug Effects Biofilms Drug Effects Human Randomized Controlled Trials Random Assignment Dental Scaling Root Planing Metronidazole Administration and Dosage Amoxicillin Administration and Dosage Polymerase Chain Reaction Methods Treatment Outcomes Brazil Specimen Handling Methods Gene Amplification One-Way Analysis of Variance Post Hoc Analysis Analysis of Covariance McNemar's Test Chi Square Test T-Tests Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years ab: Objective: The aim of this randomized double‐blind and placebo‐controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the mean level of Archaea. Methods: Fifty‐nine (59) subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ; 400 mg/TID) or either with MTZ and amoxicillin (AMX; 500 mg/TID) for 14 days. Clinical and microbiological examinations were performed at baseline and at 6 months post‐SRP. Six subgingival plaque samples per subject were analysed for the presence and levels of Archaea using quantitative polymerase chain reaction. Results: Scaling and root planing alone or combined with MTZ or MTZ + AMX significantly reduced the prevalence of subjects colonized by Archaea at 6 months post‐therapy, without significant differences among groups (P > .05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (P < .05). The MTZ and MTZ + AMX group had a significantly lower mean number of sites colonized by Archaea and lower levels of these micro‐organisms at sites with probing depth ≥5 mm at 6 months compared with SRP group (P < .05). Conclusion: Periodontal treatments including adjunctive MTZ or MTZ + AMX are more effective than mechanical treatment alone in reducing the levels and prevalence of sites colonized by Archaea in subjects with chronic periodontitis. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|