Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow.
The advent of multifunctional nanoparticle has enabled numerous innovative strategies in diagnostics, imaging, and cancer therapy. Despite the intense research efforts in developing new nanoparticles and surface bonding ligands, one major obstacle in achieving highly effective treatment, including m...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 56; no. 11; pp. 1949 - 1959 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132461114&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132461114 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Nov2018 vid: 56 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132461114 132461114 NLM29696590 10.1007/s11517-018-1818-z NLM29696590 132461114 ppf: 1949 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow. aug: au: Xu, Zelin Kleinstreuer, Clement affil: Department of Mechanical and Aerospace Engineering, North Carolina State University, 911 Oval Dr, 27695-7910, Raleigh, NC, USA sug: subj: Blood Circulation Physiology Neoplasms Drug Therapy Nanoparticles Drugs Drug Delivery Systems Methods Physiochemical Phenomena Diffusion Particle Size Computer Simulation ab: The advent of multifunctional nanoparticle has enabled numerous innovative strategies in diagnostics, imaging, and cancer therapy. Despite the intense research efforts in developing new nanoparticles and surface bonding ligands, one major obstacle in achieving highly effective treatment, including minimizing detrimental side effects, is the inability to deliver drug-carrying nanoparticles from the injection point directly to the tumor site. The present study seeks to employ a direct nanodrug delivery methodology to feed multifunctional nanoparticles directly to tumor vasculatures, sparing healthy tissue. An important aspect to examine is how the interactions between such nanoparticles and relatively large red blood cells would affect the transport and delivery efficiency of nanodrugs. So, a novel computer simulation model has been developed to study nanoparticle transport in a representative human hepatic artery system, subject to shear-induced diffusion of nanoparticles due to hydrodynamic interactions with red blood cells. The particle-size effect was also evaluated by comparing the dynamics of nanoparticles with microspheres. Results from computer simulations under physiologically realistic conditions indicate that shear-induced diffusion has a significant effect on nanoparticle transport, even in large arteries. Nevertheless, as documented, direct nanodrug delivery to tumor-feeding hepatic artery branches is feasible. Graphical abstract Direct nanodrug delivery from injection point to tumor-feeding artery branch. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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