Filtered maximum likelihood expectation maximization based global reconstruction for bioluminescence tomography.
The reconstruction of bioluminescence tomography (BLT) is severely ill-posed due to the insufficient measurements and diffuses nature of the light propagation. Predefined permissible source region (PSR) combined with regularization terms is one common strategy to reduce such ill-posedness. However,...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 56; no. 11; pp. 2067 - 2082 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132461125&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132461125 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Nov2018 vid: 56 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132461125 132461125 NLM29770920 10.1007/s11517-018-1842-z NLM29770920 132461125 ppf: 2067 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Filtered maximum likelihood expectation maximization based global reconstruction for bioluminescence tomography. aug: au: Yang, Defu Wang, Lin Chen, Dongmei Yan, Chenggang He, Xiaowei Liang, Jimin Chen, Xueli affil: Institute of Information and Control, Hangzhou Dianzi University, 310018, Hangzhou, China sug: subj: Image Interpretation, Computer Assisted Methods Luminescent Measurements Methods Tomography, Optical Methods Algorithms Animals Liver Neoplasms Mice Male Scales Male ab: The reconstruction of bioluminescence tomography (BLT) is severely ill-posed due to the insufficient measurements and diffuses nature of the light propagation. Predefined permissible source region (PSR) combined with regularization terms is one common strategy to reduce such ill-posedness. However, the region of PSR is usually hard to determine and can be easily affected by subjective consciousness. Hence, we theoretically developed a filtered maximum likelihood expectation maximization (fMLEM) method for BLT. Our method can avoid predefining the PSR and provide a robust and accurate result for global reconstruction. In the method, the simplified spherical harmonics approximation (SPN) was applied to characterize diffuse light propagation in medium, and the statistical estimation-based MLEM algorithm combined with a filter function was used to solve the inverse problem. We systematically demonstrated the performance of our method by the regular geometry- and digital mouse-based simulations and a liver cancer-based in vivo experiment. Graphical abstract The filtered MLEM-based global reconstruction method for BLT. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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