Structural abnormalities detected by knee magnetic resonance imaging are common in middle-aged subjects with and without risk factors for osteoarthritis.
Background and purpose — Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with o...
| Publicado en: | Acta Orthopaedica Vol. 89; no. 5; pp. 535 - 541 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Medical Journals Sweden AB
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132556029&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132556029 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17453674 1BVL jtl: Acta Orthopaedica issn: 17453674 maglogo: N pubinfo: dt: Oct2018 vid: 89 iid: 5 pid: 59195 pub: Medical Journals Sweden AB artinfo: ui: 132556029 132556029 132556029 10.1080/17453674.2018.1495164 132556029 ppf: 535 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural abnormalities detected by knee magnetic resonance imaging are common in middle-aged subjects with and without risk factors for osteoarthritis. aug: au: Kumm, Jaanika Turkiewicz, Aleksandra Zhang, Fan Englund, Martin affil: Department of Radiology, University of Tartu, Tartu, Estonia sug: subj: Knee Joint Pathology Osteoarthritis, Knee Risk Factors Osteoarthritis, Knee Diagnosis Magnetic Resonance Imaging Methods Human Middle Age Female Bone Marrow Diseases Diagnosis Ossification, Heterotopic Diagnosis Meniscal Injuries Diagnosis Synovitis Diagnosis Cartilage Diseases Diagnosis Prevalence Confidence Intervals Scales Odds Ratio Middle Aged: 45-64 years Female ab: Background and purpose — Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with or without OA risk factors. Patients and methods — 340 subjects from the Osteoarthritis Initiative, aged 45-55 years (51% women) with Kellgren-Lawrence grade 0 in both knees, who had 3T knee MR images were eligible. 294 subjects had risk factors and 46 were without risk factors. MR images were assessed using the MOAKS scoring system. Results — At least 1 MR-detected feature was found in 96% (283/294) of subjects with risk factors and in 87% (40/46) of those without. Cartilage damage (82%), bone marrow lesions (60%), osteophytes (45%), meniscal body extrusion (32%), and synovitis-effusion (29%) were the most common findings in subjects with risk factors, while cartilage damage (67%), osteophytes (46%), meniscal body extrusion (37%), and bone marrow lesions (35%) were most common in subjects without. The prevalence of any abnormality was higher in subjects with OA risk factors than in subjects without (prevalence ratio adjusted for age and sex 1.3 [95% CI 1.1-1.6]), so was prevalence of subchondral cysts and bone marrow lesions. MR-detected structural changes were more frequent in patellofemoral joints. Interpretation — Our findings highlight the great challenge in distinguishing pathological features of early knee OA from what could be considered part of “normal ageing.” Bone marrow lesions were more frequently found in subjects with multiple OA risk factors. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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