Atrial natriuretic peptide accelerates human endothelial progenitor cell–stimulated cutaneous wound healing and angiogenesis.
Atrial natriuretic peptide (ANP) is a powerful vasodilating peptide secreted by cardiac muscle cells, and endothelial progenitor cells (EPCs) have been reported to stimulate cutaneous wound healing by mediating angiogenesis. To determine whether ANP can promote the EPC‐mediated repair of injured tis...
| Publicado en: | Wound Repair & Regeneration Vol. 26; no. 2; pp. 116 - 127 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar/Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132579338&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132579338 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Mar/Apr2018 vid: 26 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 132579338 132579338 132579338 10.1111/wrr.12641 132579338 ppf: 116 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Atrial natriuretic peptide accelerates human endothelial progenitor cell–stimulated cutaneous wound healing and angiogenesis. aug: au: Lee, Tae Wook Kwon, Yang Woo Park, Gyu Tae Do, Eun Kyoung Yoon, Jung Won Kim, Seung‐Chul Ko, Hyun‐Chang Kim, Moon‐Bum Kim, Jae Ho affil: Department of Physiology, Pusan National University School of Medicine, Yangsan, Republic of Korea sug: subj: Atrial Natriuretic Factor Pharmacodynamics Epithelial Cells Drug Effects Wound Healing Drug Effects Neovascularization, Physiologic Drug Effects Human In Vitro Studies Cell Movement Drug Effects Cell Proliferation Drug Effects RNA Drug Effects Natriuretic Peptides Drug Effects Animal Studies Atrial Natriuretic Factor Administration and Dosage In Vivo Studies Survival Blood Vessels Drug Effects Epithelial Cells Transplantation ab: Atrial natriuretic peptide (ANP) is a powerful vasodilating peptide secreted by cardiac muscle cells, and endothelial progenitor cells (EPCs) have been reported to stimulate cutaneous wound healing by mediating angiogenesis. To determine whether ANP can promote the EPC‐mediated repair of injured tissues, we examined the effects of ANP on the angiogenic properties of EPCs and on cutaneous wound healing. In vitro, ANP treatment enhanced the migration, proliferation, and endothelial tube‐forming abilities of EPCs. Furthermore, small interfering RNA‐mediated silencing of natriuretic peptide receptor‐1, which is a receptor for ANP, abrogated ANP‐induced migration, tube formation, and proliferation of EPCs. In a murine cutaneous wound model, administration of either ANP or EPCs had no significant effect on cutaneous wound healing or angiogenesis in vivo, whereas the coadministration of ANP and EPCs synergistically potentiated wound healing and angiogenesis. In addition, ANP promoted the survival and incorporation of transplanted EPCs into newly formed blood vessels in wounds. These results suggest ANP accelerates EPC‐mediated cutaneous wound healing by promoting the angiogenic properties and survival of transplanted EPCs. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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