Causal Concepts Guiding Model Specification in Systems Biology.
In this paper I analyze the process by which modelers in systems biology arrive at an adequate representation of the biological structures thought to underlie data gathered from high-throughput experiments. Contrary to views that causal claims and explanations are rare in systems biology, I argue th...
| Publicado en: | Disputatio: International Journal of Philosophy Vol. 9; no. 47; pp. 499 - 528 |
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| Formato: | Artículo |
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Paradigm Publishing Services
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=132647639&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 132647639 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 0873626X 1CM2 jtl: Disputatio: International Journal of Philosophy issn: 0873626X maglogo: N pubinfo: dt: Dec2017 vid: 9 iid: 47 pid: 35924 pub: Paradigm Publishing Services artinfo: ui: 132647639 10.1515/disp-2017-0016 ppf: 499 ppct: 29 formats: fmt: @attributes: type: P size: 1.6MB tig: atl: Causal Concepts Guiding Model Specification in Systems Biology. aug: au: Matthiessen, Dana affil: University of Pittsburgh su: Systems biology Causal models Underdetermination (Theory of knowledge) Genetic regulation Causation (Philosophy) sug: subj: Systems biology Causal models Underdetermination (Theory of knowledge) Genetic regulation Causation (Philosophy) keyword: causal models Causation cellular networks systems biology underdetermination ab: In this paper I analyze the process by which modelers in systems biology arrive at an adequate representation of the biological structures thought to underlie data gathered from high-throughput experiments. Contrary to views that causal claims and explanations are rare in systems biology, I argue that in many studies of gene regulatory networks modelers aim at a representation of causal structure. In addressing modeling challenges, they draw on assumptions informed by theory and pragmatic considerations in a manner that is guided by an interventionist conception of causal structure. While doubts have been raised about the applicability of this notion of causality to complex biological systems, it is here seen to be an adequate guide to inquiry. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Disputatio: International Journal of Philosophy is the property of Paradigm Publishing Services and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Disputatio: International Journal of Philosophy holder: Paradigm Publishing Services dt: @attributes: year: 2017 holdings: @attributes: islocal: N |
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