EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations.
A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a d...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 45; no. 13; pp. 2456 - 2475 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132698984&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132698984 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Dec2018 vid: 45 iid: 13 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132698984 10.1007/s00259-018-4136-7 132698984 ppf: 2456 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations. aug: au: Gear, Jonathan I. Murray, Iain Flux, Glenn D. Cox, Maurice G. Gustafsson, Johan Gleisner, Katarina Sjögreen Glatting, Gerhard Konijnenberg, Mark affil: The Royal Marsden NHS Foundation Trust & Institute of Cancer Research, Downs Road, SM2 5PT, Sutton, UK sug: ab: A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time-activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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