TERT promoter mutational screening as a tool to predict malignant behaviour in follicular thyroid tumours-three examples from the clinical routine.
Follicular thyroid adenomas (FTAs) and carcinomas (FTCs), collectively the most common thyroid neoplasms, constitute a significant clinical challenge since histological evidence of invasive behaviour is required for a malignant diagnosis. Small subsets of FTAs relapse as manifest malignant FTCs, ind...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 473; no. 5; pp. 639 - 644 |
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| Autores principales: | , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Springer Nature
Nov2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132699423&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132699423 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Nov2018 vid: 473 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132699423 132699423 NLM29860621 132699423 10.1007/s00428-018-2386-1 NLM29860621 132699423 ppf: 639 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: TERT promoter mutational screening as a tool to predict malignant behaviour in follicular thyroid tumours-three examples from the clinical routine. aug: au: Hysek, Martin Paulsson, Johan O. Wang, Na Jatta, Kenbugul Lindh, Claes Fuentes-Martinez, Nelson Shabo, Ivan Zedenius, Jan Juhlin, C. Christofer affil: Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden sug: subj: Transferases Genetic Screening Methods Adenocarcinoma Pathology Thyroid Neoplasms Pathology Mutation Adenocarcinoma Aged Thyroid Neoplasms Middle Age Female Thyroid Neoplasms Diagnosis Adenocarcinoma Diagnosis Male Scales Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Follicular thyroid adenomas (FTAs) and carcinomas (FTCs), collectively the most common thyroid neoplasms, constitute a significant clinical challenge since histological evidence of invasive behaviour is required for a malignant diagnosis. Small subsets of FTAs relapse as manifest malignant FTCs, indicating that histology is not always adequate to predict malignant potential. Lately, recurrent mutations in the promoter of the Telomerase reverse transcriptase (TERT) gene have been coupled to FTCs, whereas FTAs usually lack this aberrancy. We describe three patients with follicular thyroid tumours in which TERT promoter mutational screening was employed as part of the clinical work-up to pinpoint malignant potential. In two retrospective analyses of seemingly benign lesions, the detected mutations predicted future skeletal metastases, and in one prospective case, the mutational screening led to a different clinical management of the afflicted patient. We therefore consider TERT promoter mutational screening an adjunct tool of value in equivocal cases. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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