The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene-Gene-Environment Study.
Behavioral genetics studies and new empirical evidence suggest that depression cannot simply be explained by the influence of single genes but that gene-gene-environment interactions are important to better understanding the etiology of depression. The present study investigated the main and interac...
| Published in: | Journal of Youth & Adolescence Vol. 47; no. 11; pp. 2468 - 2481 |
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| Main Authors: | , , , , |
| Format: | Article |
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Springer Nature
Nov2018
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=132789425&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 132789425 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00472891 JYA jtl: Journal of Youth & Adolescence issn: 00472891 maglogo: N pubinfo: dt: Nov2018 vid: 47 iid: 11 pid: 237 pub: Springer Nature artinfo: ui: 132789425 10.1007/s10964-018-0925-3 ppf: 2468 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P size: 696KB tig: atl: The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene-Gene-Environment Study. aug: au: Cao, Yanmiao Lin, Xiaonan Chen, Liang Ji, Linqin Zhang, Wenxin affil: Department of psychology, Shandong Normal University, Jinan, China su: Peer relations Affinity groups Self-evaluation Interpersonal relations Depression in adolescence Catechol-O-methyltransferase Dopamine Saliva analysis Methyltransferases Membrane transport proteins sug: subj: Peer relations Affinity groups Self-evaluation Interpersonal relations Depression in adolescence Catechol-O-methyltransferase Dopamine Saliva analysis Methyltransferases Membrane transport proteins keyword: Adolescent depressive symptoms COMT gene DAT1 gene Gene-gene-environment interaction Peer acceptance Peer rejection Adolescent depressive symptoms COMT gene DAT1 gene Gene-gene-environment interaction Peer acceptance Peer rejection ab: Behavioral genetics studies and new empirical evidence suggest that depression cannot simply be explained by the influence of single genes but that gene-gene-environment interactions are important to better understanding the etiology of depression. The present study investigated the main and interactive effects of COMT gene Val158Met polymorphism, DAT1 gene rs27072 polymorphism, and peer relationships (i.e., peer acceptance and rejection) on adolescent depressive symptoms. In a sample of 1045 Chinese Han adolescents (M = 12.34 ± 0.47 years, 50.1% girls), saliva samples, self-reported depressive symptoms and within-classroom peer nominations were collected. After controlling for gender, age, and SES, the three-way interaction of COMT, DAT1, and peer acceptance significantly concurrently predicted adolescent depressive symptoms. Adolescents with ValVal genotype of COMT and CC genotype of DAT1 were more sensitive to acceptance, compared to their counterparts carrying other combined genotypes. However, a similar three-way interaction was not significant in the case of peer rejection. Additionally, the split-half validation generally replicated these findings. More importantly, this study underscores complex polygenic underpinnings of depression and lends support for the gene-gene-environment interactions implicated in the etiology of depressive symptoms. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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