Dermatoglyphics in children prenatally exposed to alcohol: Fluctuating asymmetry (FA) as a biomarker of alcohol exposure.
Background: Dermatoglyphics alterations have been demonstrated to be an effective complement in the diagnosis of developmental disorders and a marker of prenatal stress. Several genetic and environmental factors can modify their morphology. Once defined, dermatoglyphics remain constant throughout li...
| Published in: | Early Human Development Vol. 127; pp. 90 - 96 |
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| Main Authors: | , , , , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Dec2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132853746&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132853746 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03783782 3K7 jtl: Early Human Development issn: 03783782 maglogo: N pubinfo: dt: Dec2018 vid: 127 pid: 1004 pub: Elsevier B.V. artinfo: ui: 132853746 132853746 NLM30393042 132853746 10.1016/j.earlhumdev.2018.10.007 NLM30393042 132853746 ppf: 90 ppct: 6 formats: tig: atl: Dermatoglyphics in children prenatally exposed to alcohol: Fluctuating asymmetry (FA) as a biomarker of alcohol exposure. aug: au: Planas, Sabina Andreu-Fernández, Vicente Martín, Maria de Castro-Catala, Marta Bastons-Compta, Adriana García-Algar, Oscar Rosa, Araceli affil: Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona (UB), Barcelona, Spain sug: subj: Dermatoglyphics Prenatal Exposure Delayed Effects Ethanol Female Human Pregnancy Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Female Male ab: Background: Dermatoglyphics alterations have been demonstrated to be an effective complement in the diagnosis of developmental disorders and a marker of prenatal stress. Several genetic and environmental factors can modify their morphology. Once defined, dermatoglyphics remain constant throughout life, being considered fossilized markers of the intrauterine development. Variations in bilateral morphological traits within an individual reflect developmental disturbances and can be measured by fluctuating asymmetry. The aim of this study was to evaluate if dermatoglyphic variations can be used as a surrogate marker prenatal alcohol exposure (PAE) during foetal development. Dermatoglyphics from 58 individuals who were either exposed or non-exposed to alcohol during pregnancy (according to the levels of Fatty Acid Ethyl Ethers (FAEE) found in meconium at birth) were analyzed.Methods: Total a-b ridge count (TABRC) and levels of fluctuating asymmetry from the a-b ridge count (FAABRC) were obtained.Results: A significant correlation between FA and FAEE levels was found in prenatally alcohol exposed individuals (r = 0.64, p = 0.0032). Remarkably, samples with highest values of FAEEs showed greater FAABRC (6.33 ± 4.18) levels than the values of non-exposed to alcohol (2.87 ± 1.74) as well as the exposed at low concentrations (2.6 ± 1.43) (U = 61, p = 0.05 and U = 14.5, p = 0.05, respectively).Conclusion: Heavy prenatal ethanol exposure (demonstrated by high levels of FAEEs) alters the neuroectoderm developmental program during pregnancy: PAE correlates with FAABRC, which behaves as a dermatoglyphic variable sensitive to FASD and deserves to be studied as a surrogate marker of neurodevelopmental damage during foetal development. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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