MRI assessment of the thigh musculature in dermatomyositis and healthy subjects using diffusion tensor imaging, intravoxel incoherent motion and dynamic DTI.
Introduction: Dermatomyositis (DM) is an idiopathic inflammatory myopathy involving severe debilitation in need of diagnostics. We evaluated the proximal lower extremity musculature with diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM) and dynamic DTI in DM patients and controls a...
| Publicado en: | European Radiology Vol. 28; no. 12; pp. 5304 - 5316 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=132880993&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 132880993 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2018 vid: 28 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 132880993 132880993 NLM29869178 132880993 10.1007/s00330-018-5458-3 NLM29869178 132880993 ppf: 5304 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: MRI assessment of the thigh musculature in dermatomyositis and healthy subjects using diffusion tensor imaging, intravoxel incoherent motion and dynamic DTI. aug: au: Sigmund, E. E. Baete, S. H. Luo, T. Patel, K. Wang, D. Rossi, I. Duarte, A. Bruno, M. Mossa, D. Femia, A. Ramachandran, S. Stoffel, D. Babb, J. S. Franks, A. G. Bencardino, J. affil: Department of Radiology, New York University Langone Medical Center, 660 First Ave., 10016, New York, NY, USA sug: subj: Muscle, Skeletal Dermatomyositis Diagnosis Exercise Magnetic Resonance Imaging Methods Aged Dermatomyositis Physiopathology Young Adult Adult Female Male Thigh Reproducibility of Results Middle Age Muscle, Skeletal Physiopathology Human Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Introduction: Dermatomyositis (DM) is an idiopathic inflammatory myopathy involving severe debilitation in need of diagnostics. We evaluated the proximal lower extremity musculature with diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM) and dynamic DTI in DM patients and controls and compared with standard clinical workup. METHODS: In this IRB-approved, HIPAA-compliant study with written informed consent, anatomical, Dixon fat/water and diffusion imaging were collected in bilateral thigh MRI of 22 controls and 27 DM patients in a 3T scanner. Compartments were scored on T1/T2 scales. Single voxel dynamic DTI metrics in quadriceps before and after 3-min leg exercise were measured. Spearman rank correlation and mixed model analysis of variance/covariance (ANOVA/ANCOVA) were used to correlate with T1 and T2 scores and to compare patients with controls.Results: DM patients showed significantly lower pseudo-diffusion and volume in quadriceps than controls. All subjects showed significant correlation between T1 score and signal-weighted fat fraction; tissue diffusion and pseudo-diffusion varied significantly with T1 and T2 score in patients. Radial and mean diffusion exercise response in patients was significantly higher than controls.Conclusion: Static and dynamic diffusion imaging metrics show correlation with conventional imaging scores, reveal spatial heterogeneity, and provide means to differentiate dermatomyositis patients from controls.Key Points: • Diffusion imaging shows regional differences between thigh muscles of dermatomyositis patients and controls. • Signal-weighted fat fraction and diffusion metrics correlate with T1/T2 scores of disease severity. • Dermatomyositis patients show significantly higher radial diffusion exercise response than controls. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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