A new risk stratification score for the management of ultrasound‐detected B3 breast lesions.
To develop a predictive scoring system for ultrasound‐detected B3 lesions at ultrasound‐guided core needle biopsy (US‐CNB). A total of 2724 consecutive US‐CNBs performed in our Institution (January 2011 to December 2014) were retrospectively reviewed. Inclusion criteria were as follows: (a) histopat...
| Publicado en: | Breast Journal Vol. 24; no. 6; pp. 965 - 971 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov/Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133048150&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133048150 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: Nov/Dec2018 vid: 24 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 133048150 133048150 133048150 10.1111/tbj.13115 133048150 ppf: 965 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: A new risk stratification score for the management of ultrasound‐detected B3 breast lesions. aug: au: Giuliani, Michela Rinaldi, Pierluigi Rella, Rossella D'Angelo, Anna Carlino, Giorgio Infante, Amato Romani, Maurizio Bufi, Enida Belli, Paolo Manfredi, Riccardo affil: Department of Radiology, Catholic University of the Sacred Heart, Rome Italy sug: subj: Risk Assessment Breast Neoplasms Diagnosis Breast Neoplasms Surgery Ultrasonography Methods Biopsy, Needle Methods Breast Neoplasms Risk Factors Human Breast Neoplasms Pathology Retrospective Design Predictive Value of Tests Hyperplasia Surgery Carcinoma, Lobular Surgery Carcinoma, Papillary Surgery Neoplasms, Fibroepithelial Surgery Odds Ratio ab: To develop a predictive scoring system for ultrasound‐detected B3 lesions at ultrasound‐guided core needle biopsy (US‐CNB). A total of 2724 consecutive US‐CNBs performed in our Institution (January 2011 to December 2014) were retrospectively reviewed. Inclusion criteria were as follows: (a) histopathological examination of the entire lesion or (b) availability of radiologic follow‐up (FUP) ≥24 months. Patient‐ and lesion‐related variables—patients' age, lesion consistency, lesion size, vascularization, BI‐RADS category, and US‐CNB result—were analyzed. Positive predictive values (PPVs) for malignancy were calculated correlating US‐CNB results with excision histology or FUP. A scoring system for underlying malignancy was developed using risk factors weighting. A total of 102 B3 lesions were included: 27 atypical ductal hyperplasia (26.5%), 5 lobular intraepithelial neoplasia (4.9%), 32 radial scar (31.4%), 37 papillary lesions (36.3%), and 1 fibroepithelial lesion (0.9%). Surgery was performed on 71/102 (69.6%) lesions, and 22/71 were malignant; the remaining 31/102 lesions (30.4%) were unchanged at FUP. The overall PPV for malignancy was 21.6%. Patients' age (odds ratio [OR] = 3.63, P = 0.008), lesion consistency (OR = 5.96, P = 0.001), BI‐RADS category (OR = 17.52, P < 0.001), and CNB result (OR = 3.6, P = 0.008) were associated with a higher risk of malignancy underestimation and selected as risk factors in the score definition. Two risk groups were identified: low (0‐2 points) and high risk (3‐5 points), with significantly different risk of malignancy underestimation (8.0% vs 59.3%, P < 0.001). The proposed score helps to predict the risk of malignancy underestimation and choose the management of B3 lesions at US‐CNB. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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