Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice.
Fasting and especially intermittent fasting have been shown to be an effective intervention in many diseases, such as obesity and diabetes. The fasting-mimicking diet (FMD) has recently been found to ameliorate metabolic disorders. To investigate the effect of a new type of low-protein low-carbohydr...
| Publicado en: | Nutrition & Metabolism Vol. 15; no. 1 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
BioMed Central
11/20/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133089600&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133089600 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 11/20/2018 vid: 15 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 133089600 133089600 133089600 10.1186/s12986-018-0318-3 133089600 ppct: 1 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. aug: au: Wei, Siying Han, Ruomei Zhao, Jingyu Wang, Shuo Huang, Meiqin Wang, Yining Chen, Yan affil: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Rd, 200031, Shanghai, China sug: subj: Diabetes Mellitus, Type 2 Diet Therapy Gut Microbiota Drug Effects Restricted Diet Diet, Low Carbohydrate Islets of Langerhans Drug Effects Dietary Carbohydrates Pharmacodynamics Dietary Proteins Pharmacodynamics Fasting Disease Progression Animal Studies Mice Blood Glucose Drug Effects Insulin Sensitivity Fatty Liver Gene Expression Drug Effects Bacteroides Drug Effects Gram-Negative Anaerobic Bacteria Drug Effects Gram-Positive Bacteria Drug Effects ab: Fasting and especially intermittent fasting have been shown to be an effective intervention in many diseases, such as obesity and diabetes. The fasting-mimicking diet (FMD) has recently been found to ameliorate metabolic disorders. To investigate the effect of a new type of low-protein low-carbohydrate FMD on diabetes, we tested an FMD in db/db mice, a genetic model of type 2 diabetes. The diet was administered every other week for a total of 8 weeks. The intermittent FMD normalized blood glucose levels in db/db mice, with significant improvements in insulin sensitivity and β cell function. The FMD also reduced hepatic steatosis in the mice. Deterioration of pancreatic islets and the loss of β cells in the diabetic mice were prevented by the FMD. The expression of β cell progenitor marker Ngn3 was increased by the FMD. In addition, the FMD led to the reconstruction of gut microbiota. Intermittent application of the FMD increased the genera of Parabacteroides and Blautia while reducing Prevotellaceae, Alistipes and Ruminococcaceae. The changes in these bacteria were also correlated with the fasting blood glucose levels of the mice. Furthermore, intermittent FMD was able to reduce fasting blood glucose level and increase β cells in STZ-induced type 1 diabetic mouse model. In conclusion, our study provides evidence that the intermittent application of an FMD is able to effectively intervene in the progression of diabetes in mice. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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