White matter involvement in young non-demented Down’s syndrome subjects: a tract-based spatial statistic analysis.
Purpose: Cognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer’s disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, wit...
| Publicado en: | Neuroradiology Vol. 60; no. 12; pp. 1335 - 1342 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133106541&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133106541 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Dec2018 vid: 60 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133106541 133106541 133106541 10.1007/s00234-018-2102-5 133106541 ppf: 1335 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: White matter involvement in young non-demented Down’s syndrome subjects: a tract-based spatial statistic analysis. aug: au: Romano, Andrea Moraschi, Marta Cornia, Riccardo Bozzao, Alessandro Rossi-Espagnet, Maria Camilla Giove, Federico Albertini, Giorgio Pierallini, Alberto affil: Department of Odontostomatological and Maxillo-Facial Sciences, Umberto I Hospital, University Sapienza, Via di Grottarossa, 00135, Rome, Italy sug: subj: White Matter Pathology Down Syndrome Diagnosis Dementia Magnetic Resonance Imaging Methods Human Image Processing, Computer Assisted Software T-Tests Down Syndrome Therapy ab: Purpose: Cognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer’s disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, without dementia, by means of DTI technique, compared to a normal control group.Methods: The study group consisted of 17 right-handed subjects with DS and many control subjects. All individuals participating in this study were examined by MR exam including DTI acquisition (32 non-coplanar directions); image processing and analysis were performed using FMRIB Software Library (FSL version 4.1.9, http://www.fmrib.ox.ac.uk/fsl)) software package. Finally, the diffusion tensor was estimated voxel by voxel and the FA map derived from the tensor. A two-sample t test was performed to assess differences between DS and control subjects.Results: The FA is decreased in DS subjects, compared to control subjects, in the region of the anterior thalamic radiation, the inferior fronto-occipital fasciculum, the inferior longitudinal fasciculum, and the cortico-spinal tract, bilaterally.Conclusions: The early white matter damage visible in our DS subjects could have great impact in the therapeutic management, in particular in better adapting the timing of therapies to counteract the toxic effect of the deposition of amyloid that leads to oxidative stress. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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