Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects.
Purpose: A multifunctional diet (MFD) targeting subclinical inflammation was developed as a tool to decrease risk factors for cardiometabolic disease in healthy “at-risk” individuals (BMI 25-33 kg/m2). MFD contains several components that are degraded in the colon by the microbiota, such as dietary...
| Publicado en: | European Journal of Nutrition Vol. 57; no. 8; pp. 2927 - 2937 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133123970&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133123970 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2018 vid: 57 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133123970 133123970 133123970 10.1007/s00394-017-1563-3 133123970 ppf: 2927 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects. aug: au: Marungruang, Nittaya Tovar, Juscelino Björck, Inger Hållenius, Frida Fåk affil: Department of Food Technology, Engineering and Nutrition, Lund University, Kemicentrum, Sölvegatan 39, SE-22100, Lund, Sweden sug: subj: Cardiovascular Risk Factors Obesity Gut Microbiota Analysis Dietary Supplementation Biological Markers Human Middle Age Aged Body Mass Index Sequence Analysis Methods RNA Analysis Gram-Negative Anaerobic Bacteria Blood Pressure Faecalibacterium Lipids Blood Middle Aged: 45-64 years Aged: 65+ years ab: Purpose: A multifunctional diet (MFD) targeting subclinical inflammation was developed as a tool to decrease risk factors for cardiometabolic disease in healthy “at-risk” individuals (BMI 25-33 kg/m2). MFD contains several components that are degraded in the colon by the microbiota, such as dietary fibers from rye, barley, oats and berries. It also contains soy beans, oily fish and plant stanols. In previous studies, we have observed improved cardiometabolic markers in healthy at-risk individuals after 4-8 week intake of MFD. However, whether these improvements can be associated with changes in the gut microbiota composition has not been investigated. In the present study, we analyzed the gut microbiota before and after an 8-week dietary intervention with MFD.Methods: Cardiometabolic at-risk individuals (n = 47), between 51 and 72 years old and with a BMI of 25-33 kg/m2, were given either the MFD or a control diet lacking the functional (“active”) components for 8 weeks in a parallel, randomized design. Next-generation sequencing of bacterial 16S rRNA genes was used to analyze the gut microbiota composition.Results: The 8-week intervention with MFD did not significantly alter the gut microbiota composition at phylum or genus taxonomic levels, while LEfSE analysis identified increased abundance of Prevotella copri in the MFD group as compared to the control group. Treponema correlated positively with blood pressure. In contrast, Faecalibacterium showed a negative association with blood pressure, while Bilophila appeared to associate with a negative blood lipid profile.Conclusions: Taken together, results from the present study may be used in the further development of effective dietary concepts capable of reducing cardiometabolic risk markers in humans through a targeted modulation of the gut microbial community.Trial registration number: Clinical Trials.gov NCT02148653. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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