Quantitative characterization of carotid plaque components using MR apparent diffusion coefficients and longitudinal relaxation rates at 3T: A comparison with histology.
Background: There is limited evidence of parametric MR mapping to characterize carotid plaques associated with cerebral ischemic events.Purpose: To explore the apparent diffusion coefficients (ADCs) and longitudinal relaxation rates (R1 ) of carotid plaques, including areas of hemorrhage, lipid-rich...
| Publicado en: | Journal of Magnetic Resonance Imaging Vol. 48; no. 6; pp. 1657 - 1668 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133218862&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133218862 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: Dec2018 vid: 48 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 133218862 133218862 NLM30325551 133218862 10.1002/jmri.26216 NLM30325551 133218862 ppf: 1657 ppct: 11 formats: tig: atl: Quantitative characterization of carotid plaque components using MR apparent diffusion coefficients and longitudinal relaxation rates at 3T: A comparison with histology. aug: au: Ota, Hideki Tamura, Hajime Itabashi, Ryo Yazawa, Yukako Nakamura, Yasuhiro Hisamatsu, Kenji Takamatsu, Manabu Endo, Hidenori Niizuma, Kuniyasu Enomoto, Yukiko Nagasaka, Tatsuo Kajita, Kimihiro Watanabe, Mika Yoshimura, Shinichi Yuan, Chun affil: Department of Diagnostic Radiology, Tohoku University Hospital, Miyagi Japan sug: subj: Histological Techniques Methods Magnetic Resonance Imaging Cerebral Ischemia Image Processing, Computer Assisted Methods Carotid Stenosis Aged, 80 and Over Middle Age Sensitivity and Specificity Cerebral Ischemia Complications Carotid Arteries Pathology Necrosis Probability Atherosclerosis Pathology Human Polyvinyls Aged Hemorrhage Female Prospective Studies Elements Lipids Image Interpretation, Computer Assisted Methods Atherosclerosis Male Carotid Stenosis Complications Phantoms, Imaging Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Aged, 80 & over Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: There is limited evidence of parametric MR mapping to characterize carotid plaques associated with cerebral ischemic events.Purpose: To explore the apparent diffusion coefficients (ADCs) and longitudinal relaxation rates (R1 ) of carotid plaques, including areas of hemorrhage, lipid-rich/necrotic core (LR/NC) without hemorrhage, and fibrous tissue (Fbr) STUDY TYPE: Prospective.Subjects: Twelve patients who underwent carotid endarterectomy.Field Strength/sequence: R1 was measured using double angle Look-Locker acquisition on 3T systems. Single-shot spin-echo echo-planar imaging with fat suppression and outer-volume suppression (OVS-DWEPI) with b values of 10 and 500 s/mm2 was used for diffusion-weighted imaging.Assessment: A phantom study using diluted gadolinium solutions and polyvinyl alcohol solutions was used to validate the two protocols. Regions of interest (ROIs) were manually outlined on MR images for areas of LR/NC, hemorrhage, and Fbr based on histological cross-sections. Pixel-based R1 and ADC values in the ROIs were plotted for each component. The probability density function of the plots determined the optimum contours to separate the three components in the ADC-R1 plane. The LR/NC, hemorrhage, and Fbr regions were mapped on MR images based on the above results and compared to histological results.Statistical Tests: The R1 values of the phantom measurements were tested using Bland-Altman analysis. The accuracies of the MRI classification were calculated.Results: R1 values <8 s-1 calculated using our method agreed with those calculated using an inversion-recovery fast-spin-echo sequence (error, ≤0.1 s-1 ). ADC values obtained using OVS-DWEPI were 4.1% higher than those obtained using standard echo-planar imaging. LR/NC (R1 , 0.4-1.2 s-1 ; ADC, 0-1.5 μm2 /ms), hemorrhage (R1 ≥ 1.5 s-1 ; ADC, 0.5-1.5 μm2 /ms), and Fbr (R1 , 0.2-0.8 s-1 ; ADC, 1.5-2.9 μm2 /ms) were separated on the plots. The accuracies of MRI classification were LR/NC, 0.86; hemorrhage, 0.79; and Fbr, 0.77.Conclusion: The combination of ADC and R1 values measured using our method enabled differentiation among LR/NC, hemorrhage, and Fbr.Level Of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1657-1667. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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