Molecular imaging with nanoparticles: the dwarf actors revisited 10 years later.
We explore present-day trends and challenges in nanomedicine. Creativity in the laboratories continues: the published literature on novel nanoparticles is now vast. Nanoagents are discussed here which are composed entirely of strongly photoluminescent materials, tunable to desired optical properties...
| Publicado en: | Histochemistry & Cell Biology Vol. 150; no. 6; pp. 733 - 795 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133242995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133242995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09486143 NQI jtl: Histochemistry & Cell Biology issn: 09486143 maglogo: N pubinfo: dt: Dec2018 vid: 150 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133242995 10.1007/s00418-018-1753-y 133242995 ppf: 733 ppct: 62 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Molecular imaging with nanoparticles: the dwarf actors revisited 10 years later. aug: au: Thurner, Gudrun C. Debbage, Paul affil: Department of Radiology, Innsbruck Medical University, 6020, Innsbruck, Austria sug: ab: We explore present-day trends and challenges in nanomedicine. Creativity in the laboratories continues: the published literature on novel nanoparticles is now vast. Nanoagents are discussed here which are composed entirely of strongly photoluminescent materials, tunable to desired optical properties and of inherently low toxicity. We focus on “quantum nanoparticles” prepared from allotropes of carbon. The principles behind strong, tunable photoluminescence are quantum mechanical: we present them in simple outline. The major industries racing to develop these materials can offer significant technical guidance to nanomedicine, which could help to custom-design strongly signalling nanoagents specifically for stated clinical applications. Since such agents are small, they can be targeted easily, making active targeting possible. We consider it timely now to study the interactions nanoparticles undergo with tissue components in living animals and to learn to understand and overcome the numerous barriers the organism interposes between the blood and targets in or on parenchymal cells. As the near infra-red spectrum opens up, detection of glowing nanoparticles several centimeters deep in a living human subject becomes calculable and we present a simple way to do this. Finally, we discuss the slow-fuse and resource-inefficient entry of nanoparticles into clinical application. A first possible reason is failure to target across the body’s barriers, see above. Second, in the sparse translational landscape funding and support gaps yawn widely between academic research and subsequent development. We consider the agendas of the numerous “stakeholders” participating in this sad landscape and point to some faint glimmers of hope for the future. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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