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Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes.

Type 1 diabetes is associated with slower psychomotor speed, but the neural basis of this relationship is not yet understood. The basal ganglia are a set of structures that are vulnerable to small vessel disease, particularly in individuals with type 1 diabetes. Thus, we examined the relationship be...

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Published in:Brain Imaging & Behavior Vol. 12; no. 5; pp. 1271 - 1279
Main Authors: Ryan, John P., Aizenstein, Howard J., Orchard, Trevor J., Nunley, Karen A., Karim, Helmet, Rosano, Caterina
Format: Journal Article
Published: Springer Nature Oct2018
Online Access:View this record in EBSCOhost
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      dt: Oct2018
      vid: 12
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s11682-017-9783-y
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        atl: Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes.
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        au:
          Ryan, John P.
          Aizenstein, Howard J.
          Orchard, Trevor J.
          Nunley, Karen A.
          Karim, Helmet
          Rosano, Caterina
        affil: Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St., 15213, Pittsburgh, PA, USA
      sug:
        subj:
          Cerebrovascular Circulation Physiology
          Psychomotor Performance
          Diabetes Mellitus, Type 1 Physiopathology
          Basal Ganglia Physiopathology
          Neuropsychological Tests
          Basal Ganglia
          Magnetic Resonance Imaging
          Male
          Adult
          Female
          Middle Age
          Gray Matter Blood Supply
          Relaxation
          Body Weights and Measures
          Gray Matter Physiopathology
          Diabetes Mellitus, Type 1
          Prospective Studies
          Gray Matter
          Basal Ganglia Blood Supply
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Type 1 diabetes is associated with slower psychomotor speed, but the neural basis of this relationship is not yet understood. The basal ganglia are a set of structures that are vulnerable to small vessel disease, particularly in individuals with type 1 diabetes. Thus, we examined the relationship between psychomotor speed and resting state resting cerebral blood flow in a sample of adults with diabetes onset during childhood (≤ 17 years of age). The sample included 77 patients (39 M, 38 F) with a mean age of 47.43 ± 5.72 years, age of onset at 8.50 ± 4.26 years, and duration of disease of 38.92 ± 4.18 years. Resting cerebral blood flow was quantified using arterial spin labeling. After covarying for sex, years of education and normalized gray matter volume, slower psychomotor speed was associated with lower cerebral blood flow in bilateral caudate nucleus-thalamus and a region in the superior frontal gyrus. These results suggest that the basal ganglia and frontal cortex may underlie slower psychomotor speed in individuals with type 1 diabetes.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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