Investigating the effects of subconcussion on functional connectivity using mass-univariate and multivariate approaches.
There are concerns about the effects of subconcussive head impacts in sport, but the effects of subconcussion on brain connectivity are not well understood. We hypothesized that college football players experience changes in brain functional connectivity not found in athletes competing in lower impa...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 5; pp. 1332 - 1346 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133509394&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133509394 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2018 vid: 12 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133509394 133509394 NLM29188492 10.1007/s11682-017-9790-z NLM29188492 133509394 ppf: 1332 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Investigating the effects of subconcussion on functional connectivity using mass-univariate and multivariate approaches. aug: au: Reynolds, Bryson B. Stanton, Amanda N. Soldozy, Sauson Goodkin, Howard P. Wintermark, Max Druzgal, T. Jason affil: Department of Radiology and Medical Imaging, Division of Neuroradiology, University of Virginia, 22908, Charlottesville, VA, USA sug: subj: Magnetic Resonance Imaging Methods Brain Physiopathology Brain Mapping Methods Brain Brain Concussion Brain Concussion Physiopathology Football Young Adult Male Athletes Colleges and Universities Racquet Sports Athletic Injuries Physiopathology Athletic Injuries Relaxation Multivariate Analysis Soccer Clinical Assessment Tools Impact of Events Scale Scales Male ab: There are concerns about the effects of subconcussive head impacts in sport, but the effects of subconcussion on brain connectivity are not well understood. We hypothesized that college football players experience changes in brain functional connectivity not found in athletes competing in lower impact sports or healthy controls. These changes may be spatially heterogeneous across participants, requiring analysis methods that go beyond mass-univariate approaches commonly used in functional MRI (fMRI). To test this hypothesis, we analyzed resting-state fMRI data from college football (n = 15), soccer (n = 12), and lacrosse players (n = 16), and controls (n = 29) collected at preseason and postseason time points. Regional homogeneity (ReHo) and degree centrality (DC) were calculated as measures of local and long-range functional connectivity, respectively. Standard voxel-wise analysis and paired support vector machine (SVM) classification studied subconcussion's effects on local and global functional connectivity. Voxel-wise analyses yielded minimal findings, but SVM classification had high accuracy for college football's ReHo (87%, p = 0.009) and no other group. The findings suggest subconcussion results in spatially heterogeneous changes in local functional connectivity that may only be detectible with multivariate analyses. To determine if voxel-wise and SVM analyses had similar spatial patterns, region-average t-statistic and SVM weight values were compared using a measure of ranking distance. T-statistic and SVM weight rankings exhibited significantly low ranking distance values for all groups and metrics, demonstrating that the analyses converged on a similar underlying effect. Overall, this research suggests that subconcussion in football may produce local functional connectivity changes similar to concussion. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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