Altered connectivity patterns among resting state networks in patients with ischemic white matter lesions.
White matter lesions (WMLs) have been associated with cognitive and motor decline. Resting state networks (RSNs) are spatially coherent patterns in the human brain and their interactions sustain our daily function. Therefore, investigating the altered intra- and inter-network connectivity among the...
| Published in: | Brain Imaging & Behavior Vol. 12; no. 5; pp. 1239 - 1251 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Oct2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133509396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133509396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2018 vid: 12 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133509396 133509396 NLM29134612 10.1007/s11682-017-9793-9 NLM29134612 133509396 ppf: 1239 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered connectivity patterns among resting state networks in patients with ischemic white matter lesions. aug: au: Ding, Ju-Rong Ding, Xin Hua, Bo Xiong, Xingzhong Wen, Yuqiao Ding, Zhongxiang Wang, Qingsong Thompson, Paul affil: School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, China sug: subj: Cerebral Ischemia Brain Physiopathology Cerebral Ischemia Physiopathology Cognition Brain Neural Pathways Middle Age Neural Pathways Physiopathology Male Magnetic Resonance Imaging Aged Brain Mapping Female Relaxation Cerebral Ischemia Psychosocial Factors Middle Aged: 45-64 years Aged: 65+ years Male Female ab: White matter lesions (WMLs) have been associated with cognitive and motor decline. Resting state networks (RSNs) are spatially coherent patterns in the human brain and their interactions sustain our daily function. Therefore, investigating the altered intra- and inter-network connectivity among the RSNs may help to understand the association of WMLs with impaired cognitive and motor function. Here, we assessed alterations in functional connectivity patterns based on six well-defined RSNs-the default mode network (DMN), dorsal attention network (DAN), frontal-parietal control network (FPCN), auditory network (AN), sensory motor network (SMN) and visual network (VN)-in 15 patients with ischemic WMLs and 15 controls. In the patients, Spearman's correlation analysis was further performed between these alterations and cognitive test scores, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Our results showed wide alterations of inter-network connectivity mainly involving the SMN, DMN, FPCN and DAN, and some alterations correlated with cognitive test scores in the patients. The reduced functional connectivities in the SMN-AN, SMN-VN, FPCN-AN, DAN-VN pairs may account for the cognitive and motor decline in patients with ischemic WMLs, while the increased functional connectivities in the DMN-AN, DMN-FPCN and DAN-FPCN pairs may reflect a functional network reorganization after damage to white matter. It is unexpected that altered intra-network connectivities were found within the AN and VN, which may explain the impairments in verbal fluency and information retrieval associated with WMLs. This study highlights the importance of functional connectivity in understanding how WMLs influence cognitive and behavior dysfunction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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