Decreased interhemispheric coordination in the posterior default-mode network and visual regions as trait alterations in first-episode, drug-naive major depressive disorder.
Decreased homotopic connectivity has been implicated in the neurophysiology of major depressive disorder (MDD) with inconsistent findings. A combination of clinical and methodological variabilities may account for the inconsistency, and thus limiting the reproducibility of the findings. The present...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 5; pp. 1251 - 1259 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133509397&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133509397 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2018 vid: 12 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133509397 133509397 NLM29143911 10.1007/s11682-017-9794-8 NLM29143911 133509397 ppf: 1251 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Decreased interhemispheric coordination in the posterior default-mode network and visual regions as trait alterations in first-episode, drug-naive major depressive disorder. aug: au: Guo, Wenbin Cui, Xilong Liu, Feng Chen, Jindong Xie, Guangrong Wu, Renrong Zhang, Zhikun Chen, Huafu Zhang, Xiangyang Zhao, Jingping affil: Department of Psychiatry, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China sug: subj: Brain Depression Physiopathology Brain Physiopathology Depression Magnetic Resonance Imaging Methods Dominance, Cerebral Diagnosis, Computer Assisted Adult Sensitivity and Specificity Brain Mapping Methods Relaxation Young Adult Neural Pathways Neural Pathways Physiopathology Male Female Arthritis Impact Measurement Scales Scales Adult: 19-44 years Male Female ab: Decreased homotopic connectivity has been implicated in the neurophysiology of major depressive disorder (MDD) with inconsistent findings. A combination of clinical and methodological variabilities may account for the inconsistency, and thus limiting the reproducibility of the findings. The present study aims to examine voxel-mirrored homotopic connectivity (VMHC) alterations in two independent samples of patients with first-episode, drug-naive MDD. The samples included 59 patients and 31 controls from Sample 1 and 29 patients and 24 controls from Sample 2. VMHC was evaluated in both samples with an overlapping technique, which was used to define regions of abnormality common to both samples. Moreover, receiver operating characteristic curve and support vector machine were employed to differentiate the patients from the controls in both samples. Compared with the controls, the patients in both samples exhibited decreased VMHC in overlapped brain clusters, including the posterior cingulate cortex (PCC) and cuneus. Moreover, the VMHC values in the PCC and cuneus and a combination of the VMHC values in these two clusters could robustly discriminate between patients and controls with good sensitivities and specificities in both samples. This study is the first to examine VMHC abnormalities in first-episode, drug-naive patients with MDD in two independent samples by using an overlapped technique. The patients exhibit decreased VMHC in overlapping clusters in the posterior default-mode network and visual regions, which may be trait alterations for MDD. The present study provides a new perspective for understanding the neurophysiologic abnormalities of VMHC in MDD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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