Network-level dysconnectivity in patients with nasopharyngeal carcinoma (NPC) early post-radiotherapy: longitudinal resting state fMRI study.
In this study, we seek to longitudinally investigate the network-level functional connectivity (FC) alternations and its association with irradiation dose and cognition changes in the early stage post radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients. We performed independent component an...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 5; pp. 1279 - 1290 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133509403&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133509403 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2018 vid: 12 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133509403 133509403 NLM29164505 10.1007/s11682-017-9801-0 NLM29164505 133509403 ppf: 1279 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Network-level dysconnectivity in patients with nasopharyngeal carcinoma (NPC) early post-radiotherapy: longitudinal resting state fMRI study. aug: au: Qiu, Yingwei Guo, Zheng Han, Lujun Yang, Yadi Li, Jing Liu, Shiliang Lv, Xiaofei affil: Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 510150, Guangzhou, People's Republic of China sug: subj: Nasopharyngeal Neoplasms Physiopathology Nasopharyngeal Neoplasms Radiotherapy Brain Radiation Effects Brain Physiopathology Male Prospective Studies Neural Pathways Radiation Effects Cognition Cerebrovascular Circulation Neural Pathways Brain Antineoplastic Agents Therapeutic Use Young Adult Magnetic Resonance Imaging Adult Treatment Outcomes Oxygen Blood Nasopharyngeal Neoplasms Radiation Dosage Neural Pathways Physiopathology Middle Age Female Brain Mapping Nasopharyngeal Neoplasms Psychosocial Factors Relaxation Clinical Assessment Tools Scales Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: In this study, we seek to longitudinally investigate the network-level functional connectivity (FC) alternations and its association with irradiation dose and cognition changes in the early stage post radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients. We performed independent component analysis (ICA) of resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) from 39 newly diagnosed NPC patients before receiving treatment (baseline), and 3 months post-RT. the default mode network (DMN), salience network (SN), and executive control network (ECN) were extracted with well-validated software (GIFT). Inter-network connectivity was assessed using the functional network connectivity (FNC) toolbox. The inter- and intra-network FC was compared between time points, and the z value of FC alternation was correlated with the RT dose value and cognitive changes. Compared with baseline, the FC of the left anterior cingulate cortex (ACC) within the DMN, and the right insular within the SN, significantly reduced 3 months post-RT, with greater effects at higher doses in the right insular. Bilateral ECN FC was also significantly lower 3 months post-RT compared to the baseline. Chemotherapy was not associated with inter- and intra- network FC change. We found intra- and inter-network FC disruption in NPC patients 3 months post-RT, with the right insular showing a dose-dependent effect. Thus, this network-level FC may serve as a potential biomarker of the RT-induced brain functional impairments, and provide valuable targets for further functional recovery treatment. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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