White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity.
Frontostriatal projections have been shown to mediate impulsivity. Recent findings have demonstrated that the projection from the prefrontal cortex to the nucleus accumbens (the accumbofrontal tract) can be isolated by using probabilistic tractography on human brain MRI data, specifically, diffusion...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 5; pp. 1524 - 1529 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133509415&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133509415 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2018 vid: 12 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133509415 133509415 NLM29302916 10.1007/s11682-017-9820-x NLM29302916 133509415 ppf: 1524 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity. aug: au: Ikuta, Toshikazu del Arco, Alberto Karlsgodt, Katherine H. affil: Department of Communication Sciences and Disorders, School of Applied Sciences, University of Mississippi, 311 George Hall, 38677, University, MS, USA sug: subj: Basal Ganglia Frontal Lobe Behavior Brain Magnetic Resonance Imaging Male Adult Middle Age Female Neural Pathways Individuality Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Frontostriatal projections have been shown to mediate impulsivity. Recent findings have demonstrated that the projection from the prefrontal cortex to the nucleus accumbens (the accumbofrontal tract) can be isolated by using probabilistic tractography on human brain MRI data, specifically, diffusion tensor images (DTI). Using DTI tractography, we isolated the tract and tested its association with the impulsivity. DTI data from 143 individuals obtained from Nathan Kline Institute-Rockland Sample was used along with the impulsivity measure assessed by the UPPS (urgency, premeditation, perseverance, and sensation seeking) impulsive behavior total score. Probabilistic tractography was first performed between the prefrontal cortex and nucleus accumbens, then, as a measure of white matter integrity in the tract, fractional anisotropy was calculated for each individual's tract. In the multiple regression, accumbofrontal FA showed significant positive association with the impulsivity, suggesting that the accumbofrontal tract integrity may contribute to individual differences in impulsivity. This study bridges the literature in rodents, in which this glutamatergic projection has been shown to mediate impulsive behavior, and the findings in humans which allow the in-vivo isolation of the tract and comparison with behavior. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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