Analysis of errors made on in utero MR studies of the foetal brain in the MERIDIAN study.

Objectives: In utero magnetic resonance (iuMR) imaging to diagnose foetal brain abnormalities has been established and is supported by meta-analyses of retrospective and prospective studies. In this paper we describe and classify the iuMR errors made in the largest diagnostic accuracy study to date...

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Publicado en:European Radiology Vol. 29; no. 1; pp. 195 - 202
Autores principales: Batty, Ruth, Gawne-Cain, Mary L., Mooney, Cara, Mandefield, Laura, Bradburn, Michael, Mason, Gerald, Griffiths, Paul D.
Formato: algorithm research tables/charts Journal Article
Publicado: Springer Nature Jan2019
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Analysis of errors made on in utero MR studies of the foetal brain in the MERIDIAN study.
      aug:
        au:
          Batty, Ruth
          Gawne-Cain, Mary L.
          Mooney, Cara
          Mandefield, Laura
          Bradburn, Michael
          Mason, Gerald
          Griffiths, Paul D.
        affil: Department of Radiology, Sheffield Teaching Hospitals Trust, Sheffield, UK
      sug:
        subj:
          Brain
          Diagnostic Errors Statistics and Numerical Data
          Prenatal Diagnosis Methods
          Algorithms
          Retrospective Design
          Pregnancy
          Magnetic Resonance Imaging Methods
          Magnetic Resonance Imaging Standards
          Brain Abnormalities
          Prospective Studies
          Prenatal Diagnosis Standards
          Female
          Clinical Competence
          Human
          Fetus
          Fetus, conception to birth
          Female
      ab: Objectives: In utero magnetic resonance (iuMR) imaging to diagnose foetal brain abnormalities has been established and is supported by meta-analyses of retrospective and prospective studies. In this paper we describe and classify the iuMR errors made in the largest diagnostic accuracy study to date (MERIDIAN). We also correlate the error rates and types with the prior experience of the reporting radiologists in order to inform how to provide a national programme with the best diagnostic accuracy achievable.Methods: The MERIDIAN cohort of 570 foetus formed the basis of this study and included 40 cases with a confirmed diagnostic error, compared with the Outcome Reference Diagnosis. Analysis included the potential clinical effect of the error and classification of error type through an Expert Neuroradiological Panel re-reporting the study. Assessments were made regarding radiologists experience prior to MERIDIAN.Results: The overall confirmed error rate for iuMR was 7·0% and it was considered that there would have been an adverse effect on prognostic information in 22/40 cases if the iuMR had informed counselling. The experienced central reporter made statistically significant fewer errors than the less experienced non-central reporters (3·8% v 11·0%) and the central reporter made fewer clinically significant errors. Furthermore, the type of cognitive errors differed between central and non-central reporters.Conclusions: Although iuMR imaging improves the diagnostic accuracy of detecting foetal brain abnormalities there remains a substantial error rate, which can have major clinical significance. We have shown that error rates are lower for more experienced reporting radiologists with fewer potential deleterious clinical implications. We discuss the implications of these findings in terms of providing a uniform national service.Key Points: • Overall confirmed error rate for iuMR diagnosing foetal brain abnormalities was 7·0%. • IuMR reports had an adverse effect on counselling in 55% of error cases. • Error rates are consistently lower for more experienced radiologists. • Collaboration between radiologists, dual reporting, overseeing scan and formal training can reduce errors.
      pubtype: Academic Journal
      doctype:
        algorithm
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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