A cloud-based computer-aided detection system improves identification of lung nodules on computed tomography scans of patients with extra-thoracic malignancies.

Objectives: To compare unassisted and CAD-assisted detection and time efficiency of radiologists in reporting lung nodules on CT scans taken from patients with extra-thoracic malignancies using a Cloud-based system.Materials and Methods: Three radiologists searched for pulmonary nodules in patients...

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Publicado en:European Radiology Vol. 29; no. 1; pp. 144 - 153
Autores principales: Vassallo, Lorenzo, Traverso, Alberto, Agnello, Michelangelo, Bracco, Christian, Campanella, Delia, Chiara, Gabriele, Fantacci, Maria Evelina, Lopez Torres, Ernesto, Manca, Antonio, Saletta, Marco, Giannini, Valentina, Mazzetti, Simone, Stasi, Michele, Cerello, Piergiorgio, Regge, Daniele
Formato: diagnostic images pictorial research tables/charts Journal Article
Publicado: Springer Nature Jan2019
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
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        atl: A cloud-based computer-aided detection system improves identification of lung nodules on computed tomography scans of patients with extra-thoracic malignancies.
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          Vassallo, Lorenzo
          Traverso, Alberto
          Agnello, Michelangelo
          Bracco, Christian
          Campanella, Delia
          Chiara, Gabriele
          Fantacci, Maria Evelina
          Lopez Torres, Ernesto
          Manca, Antonio
          Saletta, Marco
          Giannini, Valentina
          Mazzetti, Simone
          Stasi, Michele
          Cerello, Piergiorgio
          Regge, Daniele
        affil: Department of Radiology at Candiolo Cancer Institute-FPO, IRCCS, Strada Provinciale 142 km 3.95, 10060, Candiolo, Turin, Italy
      sug:
        subj:
          Lung Neoplasms
          Radiographic Image Interpretation, Computer-Assisted Methods
          Middle Age
          Male
          Early Detection of Cancer Methods
          Retrospective Design
          Female
          Aged
          Aged, 80 and Over
          Observer Bias
          Reproducibility of Results
          Adult
          Tomography, X-Ray Computed Methods
          Young Adult
          Sensitivity and Specificity
          Human
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Adult: 19-44 years
          Male
          Female
      ab: Objectives: To compare unassisted and CAD-assisted detection and time efficiency of radiologists in reporting lung nodules on CT scans taken from patients with extra-thoracic malignancies using a Cloud-based system.Materials and Methods: Three radiologists searched for pulmonary nodules in patients with extra-thoracic malignancy who underwent CT (slice thickness/spacing 2 mm/1.7 mm) between September 2015 and March 2016. All nodules detected by unassisted reading were measured and coordinates were uploaded on a cloud-based system. CAD marks were then reviewed by the same readers using the cloud-based interface. To establish the reference standard all nodules ≥ 3 mm detected by at least one radiologist were validated by two additional experienced radiologists in consensus. Reader detection rate and reporting time with and without CAD were compared. The study was approved by the local ethics committee. All patients signed written informed consent.Results: The series included 225 patients (age range 21-90 years, mean 62 years), including 75 patients having at least one nodule, for a total of 215 nodules. Stand-alone CAD sensitivity for lesions ≥ 3 mm was 85% (183/215, 95% CI: 82-91); mean false-positive rate per scan was 3.8. Sensitivity across readers in detecting lesions ≥ 3 mm was statistically higher using CAD: 65% (95% CI: 61-69) versus 88% (95% CI: 86-91, p<0.01). Reading time increased by 11% using CAD (296 s vs. 329 s; p<0.05).Conclusion: In patients with extra-thoracic malignancies, CAD-assisted reading improves detection of ≥ 3-mm lung nodules on CT, slightly increasing reading time.Key Points: • CAD-assisted reading improves the detection of lung nodules compared with unassisted reading on CT scans of patients with primary extra-thoracic tumour, slightly increasing reading time. • Cloud-based CAD systems may represent a cost-effective solution since CAD results can be reviewed while a separated cloud back-end is taking care of computations. • Early identification of lung nodules by CAD-assisted interpretation of CT scans in patients with extra-thoracic primary tumours is of paramount importance as it could anticipate surgery and extend patient life expectancy.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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