Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge.
Objectives: We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT)...
| Publicado en: | European Radiology Vol. 29; no. 1; pp. 232 - 241 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133531134&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133531134 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2019 vid: 29 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133531134 133531134 NLM29992384 133531134 10.1007/s00330-018-5628-3 NLM29992384 133531134 ppf: 232 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge. aug: au: Shirvani, Saba Tokarczuk, Paweł Statton, Ben Quinlan, Marina Berry, Alaine Tomlinson, James Weale, Peter Kühn, Bernd O'Regan, Declan P. affil: Medical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, W12 0NN, London, UK sug: subj: Vasodilation Physiology Renal Artery Vasodilator Agents Pharmacodynamics Magnetic Resonance Imaging Methods Kidney Blood Supply Renal Artery Drug Effects Free Radicals Adult Renal Artery Physiology Female Reproducibility of Results Research Subjects Male Prospective Studies Adult: 19-44 years Female Male ab: Objectives: We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T1.Methods: In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots.Results: Inter-study correlation of whole-kidney RBF was good for both single-TI (r2 = 0.90), and multi-TI ASL (r2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant.Conclusions: Free-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge.Key Points: • Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T. • This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T 1 during free breathing. • This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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