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Effect of Diabetes Mellitus Type 1 Diagnosis on the Corneal Cell Densities and Nerve Fibers.

Relation of diabetes mellitus (DM) to the various stages of corneal nerve fiber damage is well accepted. A possible association between changes in the cornea of diabetic patients and diabetic retinopathy (DR), DM duration, and age at the time of DM diagnosis were evaluated. The study included 60 pat...

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Published in:Physiological Research Vol. 67; no. 6; pp. 963 - 975
Main Authors: BURDOVÁ, M. ČESKÁ, KULICH, M., DOTŘELOVÁ, D., MAHELKOVÁ, G.
Format: Journal Article
Published: Institute of Physiology, Academy of Sciences of the Czech Republic 2018
Online Access:View this record in EBSCOhost
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      dt: 2018
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      pub: Institute of Physiology, Academy of Sciences of the Czech Republic
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        10.33549/physiolres.933899
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        atl: Effect of Diabetes Mellitus Type 1 Diagnosis on the Corneal Cell Densities and Nerve Fibers.
      aug:
        au:
          BURDOVÁ, M. ČESKÁ
          KULICH, M.
          DOTŘELOVÁ, D.
          MAHELKOVÁ, G.
        affil: Department of Ophthalmology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
      sug:
      ab: Relation of diabetes mellitus (DM) to the various stages of corneal nerve fiber damage is well accepted. A possible association between changes in the cornea of diabetic patients and diabetic retinopathy (DR), DM duration, and age at the time of DM diagnosis were evaluated. The study included 60 patients with DM type 1 (DM1) and 20 healthy control subjects. The density of basal epithelial cells, keratocytes and endothelial cells, and the status of the subbasal nerve fibers were evaluated using in vivo corneal confocal microscopy. Basal epithelial cell density increased with age (p=0.026), while stromal and endothelial cell density decreased with age (p=0.003, p=0.0005, p<0.0001). After the DM1 diagnosis was established, this association with age weaken. We showed nerve fiber damage in DM1 patients (p<0.0001). The damage correlated with the degree of DR. DM1 patients with higher age at DM1 diagnosis had a higher nerve fiber density (p=0.0021). These results indicated that age at DM1 diagnosis potentially has an important effect on final nerve fiber and corneal cell density.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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