The plant extract roles on the pathogenesis of Cryptococcus neoformans...5th Iranian Congress in Medical Mycology, Tehran, Iran, Dec 4-6, 2018.
Introduction: Cryptococcus neoformans is encapsulated yeast that causes cryptococcosis. Cryptococcosis has changed from a relatively obscure fungal pathogen that infects immunocompetent patients to a leading cause of central nervous system infection in the world's enlarging immunocompromised populat...
| Publicado en: | Current Medical Mycology Vol. 4; pp. 173 - 175 |
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| Autores principales: | , , |
| Formato: | abstract proceedings Journal Article |
| Publicado: |
Mazandaran University of Medical Sciences
2018 Supplement 1
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133659580&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133659580 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 24233439 JKN0 jtl: Current Medical Mycology issn: 24233439 maglogo: N pubinfo: dt: 2018 Supplement 1 vid: 4 pid: 45683 pub: Mazandaran University of Medical Sciences artinfo: ui: 133659580 133659580 133659580 10.18502/cmm.4.S1.2018.180 133659580 ppf: 173 ppct: 2 formats: tig: atl: The plant extract roles on the pathogenesis of Cryptococcus neoformans...5th Iranian Congress in Medical Mycology, Tehran, Iran, Dec 4-6, 2018. aug: au: Hassanpour, Parviz Morovati, Hamid Nami, Sanam affil: Department of Medical Mycology and Parasitology, school of Medicine, Tabriz university of Medical Sciences, Tabriz, Iran sug: subj: Plant Extracts Pharmacodynamics Cryptococcus Drug Effects Cryptococcosis Drug Therapy Congresses and Conferences Iran Iran ab: Introduction: Cryptococcus neoformans is encapsulated yeast that causes cryptococcosis. Cryptococcosis has changed from a relatively obscure fungal pathogen that infects immunocompetent patients to a leading cause of central nervous system infection in the world's enlarging immunocompromised populations. Two species in particular, C. neoformans (three serotypes: A, D, and AD) and C. gattii (two serotypes: B and C), are considered dangerous to humans. Two varieties of C. neoformans have been distinguished: C. neoformans var. neoformans and C. neoformans var. grubii. Cryptococcosis is a worldwide infection especially in North America and sub-Sahara Africa. Cryptococcal infections have been infrequently reported from Iran. The first published data is related to study from 1970. Most of the antifungal agents are classified in the azole antifungal drugs, especially fluconazole and echinocandins drugs. Due to the increased resistance to azoles and echinocandins, the application of medicinal plants, with or without current drug strategies, in order to reduce the side effects has been gained more importance. Recent clinical trials showed that antifungal agents which extracted from natural sources (herbs) showed limited side effects with high significance. Various plant extracts such as Carvacrol, Thymus vulgaris, Coreopsis Tinctoria, Laurus Nobilis, Eugenol, and Mentha Savolence have been shown to inhibit the growth levels and degradation of plasma membranes of C. neoformans. Conclusion: Cryptococcosis is the major fungal disease which has high mortality rate with vast spectrum of clinical forms. This infection is known as the third death cause among the AIDS patients. Due to the raising of different spectrum of side effects following the use of antibiotics (chief among them azoles), and also due to the expensive treatment costs that cause the unavailability to these drugs, special attention should be paid to this field. Studies showed that the use of plants and their components play effective roles in the growth and fine-tuning of fungal gene expression, furthermore, on the capsules biosynthesis and pathogenicity C. neoformanse. Application of studied plant extracts can be replaced by current strategies in order to the therapeutic goals for treatment of cryptococcosis. pubtype: Academic Journal doctype: abstract proceedings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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