Diffusion tensor imaging changes following mild, moderate and severe adult traumatic brain injury: a meta-analysis.
Diffusion tensor imaging quantifies the asymmetry (fractional anisotropy; FA) and amount of water diffusion (mean diffusivity/apparent diffusion coefficient; MD/ADC) and has been used to assess white matter damage following traumatic brain injury (TBI). In healthy brains, diffusion is constrained by...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 6; pp. 1607 - 1622 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133675192&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133675192 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2018 vid: 12 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133675192 133675192 NLM29383621 133675192 10.1007/s11682-018-9823-2 NLM29383621 133675192 ppf: 1607 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diffusion tensor imaging changes following mild, moderate and severe adult traumatic brain injury: a meta-analysis. aug: au: Wallace, Erica J. Mathias, Jane L. Ward, Lynn affil: School of Psychology, Faculty of Medical & Health Sciences, University of Adelaide, Adelaide, Australia sug: subj: Brain Magnetic Resonance Imaging Human Disease Progression Severity of Illness Indices Meta Analysis Validation Studies Comparative Studies Evaluation Research Multicenter Studies Impact of Events Scale ab: Diffusion tensor imaging quantifies the asymmetry (fractional anisotropy; FA) and amount of water diffusion (mean diffusivity/apparent diffusion coefficient; MD/ADC) and has been used to assess white matter damage following traumatic brain injury (TBI). In healthy brains, diffusion is constrained by the organization of axons, resulting in high FA and low MD/ADC. Following a TBI, diffusion may be altered; however the exact nature of these changes has yet to be determined. A meta-analysis was therefore conducted to determine the location and extent of changes in DTI following adult TBI. The data from 44 studies that compared the FA and/or MD/ADC data from TBI and Control participants in different regions of interest (ROIs) were analyzed. The impact of injury severity, post-injury interval (acute: ≤ 1 week, subacute: 1 week-3 months, chronic: > 3 months), scanner details and acquisition parameters were investigated in subgroup analyses, with the findings indicating that mild TBI should be examined separately to that of moderate to severe injuries. Lower FA values were found in 88% of brain regions following mild TBI and 92% following moderate-severe TBI, compared to Controls. MD/ADC was higher in 95% and 100% of brain regions following mild and moderate-severe TBI, respectively. Moderate to severe TBI resulted in larger changes in FA and MD/ADC than mild TBI. Overall, changes to FA and MD/ADC were widespread, reflecting more symmetric and a higher amount of diffusion, indicative of white matter damage. pubtype: Academic Journal doctype: meta analysis research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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