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Abnormal functional connectivity density in sleep-deprived subjects.

Sleep deprivation (SD) can alter the intrinsic brain functional organization. However, its effects on intrinsic low-frequency connectivity in the whole brain have not been well characterized. In this study, we used voxel-based functional connectivity density (FCD) analysis to investigate the effects...

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Published in:Brain Imaging & Behavior Vol. 12; no. 6; pp. 1650 - 1658
Main Authors: Yang, Liu, Lei, Yu, Wang, Lubin, Chen, Pinhong, Cheng, Shan, Chen, Shanshan, Sun, Jicheng, Li, Yanyan, Wang, Yihan, Hu, Wendong, Yang, Zheng
Format: Journal Article
Published: Springer Nature Dec2018
Online Access:View this record in EBSCOhost
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      dt: Dec2018
      vid: 12
      iid: 6
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      pub: Springer Nature
      place: New York, New York
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        133675197
        133675197
        NLM29488149
        10.1007/s11682-018-9829-9
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        atl: Abnormal functional connectivity density in sleep-deprived subjects.
      aug:
        au:
          Yang, Liu
          Lei, Yu
          Wang, Lubin
          Chen, Pinhong
          Cheng, Shan
          Chen, Shanshan
          Sun, Jicheng
          Li, Yanyan
          Wang, Yihan
          Hu, Wendong
          Yang, Zheng
        affil: Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China
      sug:
        subj:
          Sleep Deprivation
          Brain
          Sleep Deprivation Physiopathology
          Brain Physiopathology
          Brain Mapping
          Relaxation
          Male
          Neural Pathways
          Neural Pathways Physiopathology
          Young Adult
          Magnetic Resonance Imaging
          Male
      ab: Sleep deprivation (SD) can alter the intrinsic brain functional organization. However, its effects on intrinsic low-frequency connectivity in the whole brain have not been well characterized. In this study, we used voxel-based functional connectivity density (FCD) analysis to investigate the effects of SD on the spontaneous functional organization of the brain. Thirty-seven healthy participants underwent this within-subject crossover functional magnetic resonance imaging (fMRI) study during rested wakefulness (RW) and after 36 h of total sleep deprivation (TSD). Decreased long-/short-range FCDs were observed in the posterior cingulate cortex, precuneus, inferior parietal lobule, dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and ventromedial prefrontal cortex. Increased long-/short-range FCDs were found in the sensory integration and arousal regulating areas, including the postcentral gyrus, thalamus, superior temporal gyrus, and occipital-temporal cortex. Moreover, a significant negative correlation was found between the short-range FCD of the PCC and the reaction time of Psychomotor Vigilance Task. In the present study, spontaneous functional organization with significant group-wise differences between RW and TSD sessions was identified. Our findings extend our understanding of the neural mechanism of how brain activity is altered in sleep-deprived individuals.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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