White matter integrity correlates with residual consciousness in patients with severe brain injury.
Previous studies have suggested that white matter disruption plays an important role in disorders of consciousness (DOC) after severe brain injury. Nevertheless, the integrity of white matter architecture supporting consciousness and its relations with clinical severity in patients with DOC remain t...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 6; pp. 1669 - 1678 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133675199&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133675199 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2018 vid: 12 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133675199 133675199 NLM29362992 10.1007/s11682-018-9832-1 NLM29362992 133675199 ppf: 1669 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: White matter integrity correlates with residual consciousness in patients with severe brain injury. aug: au: Wang, Lubin Yang, Yi Chen, Shanshan Ge, Mingmei He, Jianghong Yang, Zheng Lin, Pan Wu, Xinhuai affil: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Sciences, 100850, Beijing, China sug: subj: Brain Injuries Consciousness Brain Magnetic Resonance Imaging Aged Adult Brain Injuries Physiopathology Middle Age Young Adult Nerve Fibers Male Female Scales Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Previous studies have suggested that white matter disruption plays an important role in disorders of consciousness (DOC) after severe brain injury. Nevertheless, the integrity of white matter architecture supporting consciousness and its relations with clinical severity in patients with DOC remain to be established. In this study, diffusion tensor imaging (DTI) data was collected from 14 DOC patients and 15 healthy control subjects. We combined tract-based spatial statistics (TBSS) with region of interest (ROI) analysis to examine differences of DTI metrics on white matter skeletons between DOC patients and healthy controls, and the association between white matter integrity and patients' residual consciousness assessed by Coma Recovery Scale-Revised (CRS-R). We found that: (1) patients with DOC had widespread white matter integrity disruptions, especially in the fornix; (2) the alteration of white matter microstructure was mainly attributed to the increase in radial diffusivity, possibly reflecting demyelination; (3) the behavioral CRS-R assessment score was positively correlated with white matter integrity in the fornix, uncinate fasciculus, pontine crossing tract, and posterior limb of internal capsule. Our results suggest that despite the widespread abnormalities of white matter following severe brain injury, the impairment of consciousness is likely to result from disruptions of key pathways that link brain regions in distributed networks. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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