Common and distinct changes of default mode and salience network in schizophrenia and major depression.
Brain imaging reveals schizophrenia as a disorder of macroscopic brain networks. In particular, default mode and salience network (DMN, SN) show highly consistent alterations in both interacting brain activity and underlying brain structure. However, the same networks are also altered in major depre...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 6; pp. 1708 - 1720 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133675203&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133675203 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2018 vid: 12 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133675203 133675203 NLM29460166 133675203 10.1007/s11682-018-9838-8 NLM29460166 133675203 ppf: 1708 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Common and distinct changes of default mode and salience network in schizophrenia and major depression. aug: au: Shao, Junming Meng, Chun Tahmasian, Masoud Brandl, Felix Yang, Qinli Luo, Guangchun Luo, Cheng Yao, Dezhong Gao, Lianli Riedl, Valentin Wohlschläger, Afra Sorg, Christian affil: Center for Information in BioMedicine, University of Electronic Science and Technology of China, 611731, Chengdu, China sug: subj: Depression Physiopathology Schizophrenia Brain Schizophrenia Physiopathology Depression Brain Physiopathology Middle Age Human Relaxation Magnetic Resonance Imaging Body Weights and Measures Brain Mapping Neural Pathways Female Image Processing, Computer Assisted Adult Neural Pathways Physiopathology Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Brain imaging reveals schizophrenia as a disorder of macroscopic brain networks. In particular, default mode and salience network (DMN, SN) show highly consistent alterations in both interacting brain activity and underlying brain structure. However, the same networks are also altered in major depression. This overlap in network alterations induces the question whether DMN and SN changes are different across both disorders, potentially indicating distinct underlying pathophysiological mechanisms. To address this question, we acquired T1-weighted, diffusion-weighted, and resting-state functional MRI in patients with schizophrenia, patients with major depression, and healthy controls. We measured regional gray matter volume, inter-regional structural and intrinsic functional connectivity of DMN and SN, and compared these measures across groups by generalized Wilcoxon rank tests, while controlling for symptoms and medication. When comparing patients with controls, we found in each patient group SN volume loss, impaired DMN structural connectivity, and aberrant DMN and SN functional connectivity. When comparing patient groups, SN gray matter volume loss and DMN structural connectivity reduction did not differ between groups, but in schizophrenic patients, functional hyperconnectivity between DMN and SN was less in comparison to depressed patients. Results provide evidence for distinct functional hyperconnectivity between DMN and SN in schizophrenia and major depression, while structural changes in DMN and SN were similar. Distinct hyperconnectivity suggests different pathophysiological mechanism underlying aberrant DMN-SN interactions in schizophrenia and depression. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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