The relationship between voxel-based metrics of resting state functional connectivity and cognitive performance in cognitively healthy elderly adults.
In previous studies, resting-state functional connectivity (FC) metrics of specific brain regions or networks based on prior hypotheses have been correlated with cognitive performance. Without constraining our analyses to specific regions or networks, we employed whole-brain voxel-based weighted deg...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 6; pp. 1742 - 1759 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133675206&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133675206 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2018 vid: 12 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133675206 133675206 NLM29464531 10.1007/s11682-018-9843-y NLM29464531 133675206 ppf: 1742 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The relationship between voxel-based metrics of resting state functional connectivity and cognitive performance in cognitively healthy elderly adults. aug: au: Zhang, Haobo Sachdev, Perminder S. Thalamuthu, Anbupalam He, Yong Xia, Mingrui Kochan, Nicole A. Crawford, John D. Trollor, Julian N. Brodaty, Henry Wen, Wei affil: College of Psychology and Sociology, Shenzhen University, 518060, Shenzhen, China sug: subj: Brain Cognition Brain Physiology Female Neural Pathways Physiology Male Brain Mapping Magnetic Resonance Imaging Aged Prospective Studies Neural Pathways Neuropsychological Tests Aged, 80 and Over Relaxation Clinical Assessment Tools Short Portable Mental Status Questionnaire Aged: 65+ years Aged, 80 & over Female Male ab: In previous studies, resting-state functional connectivity (FC) metrics of specific brain regions or networks based on prior hypotheses have been correlated with cognitive performance. Without constraining our analyses to specific regions or networks, we employed whole-brain voxel-based weighted degree (WD), a measure of local FC strength, to be correlated with three commonly used neuropsychological assessments of language, executive function and memory retrieval in both positive and negative directions in 67 cognitively healthy elderly adults. We also divided voxel-based WD into short-ranged and long-ranged WDs to evaluate the influence of FC distance on the WD-cognition relationship, and performed three validation tests. Our results showed that for language and executive function tests, positive WD correlates were located in the frontal and temporal cortices, and negative WD correlates in the precuneus and occipital cortices; for memory retrieval, positive WD correlates were located in the inferior temporal cortices, and negative WD correlates in the anterior cingulate cortices and supplementary motor areas. An FC-distance-dependent effect was also observed, with the short-ranged WD correlates of language and executive function tests located in the medial brain regions and the long-ranged WD correlates in the lateral regions. Our findings suggest that inter-individual differences in FC at rest are predictive of cognitive ability in the elderly adults. Moreover, the distinct patterns of positive and negative WD correlates of cognitive performance recapitulate the dichotomy between task-activated and task-deactivated neural systems, implying that a competition between distinct neural systems on functional network topology may have cognitive relevance. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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