Abnormalities of white and grey matter in early multiple system atrophy: comparison of parkinsonian and cerebellar variants.
Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder with progressive motor and autonomic dysfunction. There is a paucity of information on the early neurostructural changes in MSA, especially its subtypes, MSA-P (patients with predominant parkinsonism) and MSA-C (patients with p...
| Publicado en: | European Radiology Vol. 29; no. 2; pp. 716 - 725 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133695304&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133695304 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2019 vid: 29 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133695304 133695304 NLM29974222 133695304 10.1007/s00330-018-5594-9 NLM29974222 133695304 ppf: 716 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Abnormalities of white and grey matter in early multiple system atrophy: comparison of parkinsonian and cerebellar variants. aug: au: Dash, Santosh Kumar Stezin, Albert Takalkar, Tejashree George, Lija Kamble, Nitish L Netravathi, M Yadav, Ravi Kumar, Keshav J. Ingalhalikar, Madhura Saini, Jitender Pal, Pramod Kumar affil: Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, 560029, Bangalore, Karnataka, India sug: subj: Parkinsonian Disorders Pathology Neurodegenerative Diseases Pathology Gray Matter Pathology Brain Pathology Magnetic Resonance Imaging Gray Matter Cerebellum Magnetic Resonance Imaging Methods Human Middle Age Case Control Studies Female Adult Cerebellum Pathology Parkinsonian Disorders Neurodegenerative Diseases Aged Brain Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder with progressive motor and autonomic dysfunction. There is a paucity of information on the early neurostructural changes in MSA, especially its subtypes, MSA-P (patients with predominant parkinsonism) and MSA-C (patients with predominant cerebellar signs). This study investigates the abnormalities of grey matter (GM) and white matter (WM) in early MSA and its subtypes using multi-modal voxel-based analysis.Materials and Methods: Twenty-six patients with MSA with duration of symptoms ≤ 2.5 years (mean duration: 1.6 ±0.9 years) were assessed clinically and with 3T MRI. Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) were performed to identify the structural changes in MSA and its subtypes. The GM changes and diffusion parameters of WM tracts were correlated with the clinical scores. The results were compared with MRI of 25 age- and gender-matched healthy controls.Results: The early structural changes in MSA included GM loss of the cerebellum and subcallosal gyrus with widespread involvement of supratentorial and infratentorial WM fibres. In MSA-C, GM loss was limited to the cerebellum with WM changes predominantly affecting the infratentorial WM and association tracts. In contrast, MSA-P did not demonstrate any GM loss and the WM involvement was mainly supratentorial. There was no significant correlation between structural changes and clinical severity score.Conclusion: In early MSA, WM microstructure was more affected than GM. These changes were greater in MSA-C than in MSA-P, suggesting variable deterioration in the subtypes of MSA.Key Points: • Structural changes in early multiple system atrophy were evaluated using multi-modal neuroimaging. • White matter was more affected than grey matter in early MSA. • Clinical variables did not correlate with early structural changes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|