Delayed tumour enhancement on gadoxetate-enhanced MRI is associated with overall survival in patients with colorectal liver metastases.
Objectives: To determine whether tumour enhancement on preoperative delayed-phase gadoxetate-enhanced MRI can predict long-term survival in patients with colorectal liver metastases (CRCLM) post-hepatectomy.Materials and Methods: Sixty-five patients who received a preoperative gadoxetate-enhanced MR...
| Publicado en: | European Radiology Vol. 29; no. 2; pp. 1032 - 1039 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133695321&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133695321 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2019 vid: 29 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133695321 133695321 NLM29992388 10.1007/s00330-018-5618-5 NLM29992388 133695321 ppf: 1032 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Delayed tumour enhancement on gadoxetate-enhanced MRI is associated with overall survival in patients with colorectal liver metastases. aug: au: Cheung, Helen M. C. Karanicolas, Paul J. Coburn, Natalie Seth, Vikrum Law, Calvin Milot, Laurent affil: Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Rm AB 202, M4N 3M5, Toronto, ON, Canada sug: subj: Contrast Media Pharmacodynamics Magnetic Resonance Imaging Methods Colorectal Neoplasms Pathology Liver Neoplasms Middle Age Ontario Adult Liver Neoplasms Mortality Female Aged Retrospective Design Time Factors Colorectal Neoplasms Mortality Male Liver Neoplasms Diagnosis Scales Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Objectives: To determine whether tumour enhancement on preoperative delayed-phase gadoxetate-enhanced MRI can predict long-term survival in patients with colorectal liver metastases (CRCLM) post-hepatectomy.Materials and Methods: Sixty-five patients who received a preoperative gadoxetate-enhanced MRI prior to liver resection for CRCLM from January 1, 2010, to December 31, 2012, were included in this retrospective study. Target tumour enhancement (TuEn) was calculated as the mean percentage increase in SNR from precontrast to 10-min or 20-min delayed phase for up to two target lesions. Per-patient TuEn was stratified into weak and strong enhancement based on the cut-off determined by the Youden Index for 3-year survival. Kaplan-Meier and Cox regression analyses were used to determine whether tumour enhancement could predict overall survival independent of potential confounders (clinical risk score).Results: The proportion surviving at 3 years was 85.1% in patients with strong TuEn at 10 min vs. 56.5% in those with weak TuEn at 10 min (p = 0.001). The proportion surviving at 3 years was 79.4% in patients with strong TuEn at 20 min vs. 58.7% in those with weak TuEn at 20 min (p = 0.011). After adjusting for potential confounders, the hazard ratio of death was 0.24 (p = 0.009) in patients who had weak TuEn at 10 min and 0.32 (p = 0.018) in patients who had weak TuEn at 20 min.Conclusions: Strong delayed tumour enhancement seen on gadoxetate-enhanced MRI is associated with overall survival in patients with CRCLM post-hepatectomy and may be useful for preoperative risk stratification.Key Points: • Delayed tumour enhancement of colorectal liver metastases on gadoxetate-enhanced MRI is associated with survival post-hepatectomy • Delayed tumour enhancement of colorectal liver metastases on gadoxetate-enhanced MRI can be measured at both 10 min and 20 min post-contrast injection. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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