Intravoxel incoherent motion diffusion-weighted imaging for assessment of histologic grade of hepatocellular carcinoma: comparison of three methods for positioning region of interest.
Objectives: To prospectively compare the diagnostic performances of three methods of region of interest (ROI) placement for the measurements of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in differentiating the histologic grade of hepatocellular carcinoma (HCC).Methods: Eighty-...
| Publicado en: | European Radiology Vol. 29; no. 2; pp. 535 - 545 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133695335&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133695335 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2019 vid: 29 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133695335 133695335 NLM30027411 133695335 10.1007/s00330-018-5638-1 NLM30027411 133695335 ppf: 535 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Intravoxel incoherent motion diffusion-weighted imaging for assessment of histologic grade of hepatocellular carcinoma: comparison of three methods for positioning region of interest. aug: au: Wei, Yi Gao, Feifei Wang, Min Huang, Zixing Tang, Hehan Li, Jiaxing Wang, Yi Zhang, Tong Wei, Xiaocheng Zheng, Dandan Song, Bin affil: Department of Radiology, West China Hospital, Sichuan University, 610041, Chengdu, China sug: subj: Carcinoma, Hepatocellular Liver Neoplasms Pathology Carcinoma, Hepatocellular Pathology Liver Neoplasms Human Magnetic Resonance Imaging Methods Pharmacokinetics Body Weights and Measures Neoplasm Grading Histological Techniques Middle Age Male Adult Motion Aged Female Prospective Studies ROC Curve Image Interpretation, Computer Assisted Methods Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Objectives: To prospectively compare the diagnostic performances of three methods of region of interest (ROI) placement for the measurements of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in differentiating the histologic grade of hepatocellular carcinoma (HCC).Methods: Eighty-seven patients with 91 newly diagnosed HCCs were studied using IVIM imaging. Two attending radiologists separately identified the selection of tumour tissue for ROI positioning. Three different ROI positioning methods, namely the whole tumour volume (WTV) method, three-ROI method and one-section method, were used for the measurement. Kruskal-Wallis rank test or one-way ANOVA was used to compare the difference in IVIM parameters and ADC across the three different ROI positioning methods. Spearman correlation analysis was used to determine the correlation between each parameter and Edmondson-Steiner (E-S) grade. Receiver operating characteristics (ROC) curve analyses were performed to evaluate the diagnostic performance.Results: For the ADC and ADCslow, the mean value measured by using the WTV method was significant higher than the one-section and three-ROI methods (all p < 0.01). For the ADCslow, the highest area under curve (AUC) with a value of 0.969 was obtained by using the WTV method, followed by the one-section method (AUC = 0.938) and three-ROI method (AUC = 0.873). Additionally, for the ADC, AUC values were 0.861 for WTV method, 0.840 for one-section method and 0.806 for three-ROI method.Conclusions: Different ROI positioning methods used significantly affect the IVIM parameters and ADC measurements. Measurements of ADCslow value derived from WTV method entailed the highest diagnostic performance in grading HCC.Key Points: • Diffusion MRI is useful for non-invasively differentiating the histologic grade of hepatocellular carcinoma. • Different ROI positioning methods used significantly affect the IVIM parameters and ADC measurements. • IVIM model is advantageous over mono-exponential model for assessing the histologic grade of hepatocellular carcinoma. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|